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Article Features
  Adding Carboplatin to Presurgery Chemo Improved Disease-Free Survival for Patients with TNBC
Association Between Survival and Time to Surgery/Chemotherapy For Patients with Breast Cancer
Blood Sample Analysis Finds ESR1 Gene Mutations Associated with Worse Overall Breast Cancer Survival
Cognitive-Behavioral Stress Management in Breast Cancer
Combined Imaging Modalities May Change Cancer Management
False-Positive Mammograms May Indicate Increased Risk of Breast Cancer Later
Neurotoxic Effects of Chemotherapies on Cognition in Breast Cancer Survivors
New Guidelines Address Long-Term Needs of Breast Cancer Survivors
One-Two Punch of Palbociclib and Paclitaxel Shows Promise Against Advanced Breast Cancer
Researchers Isolate Cells Implicated with Breast-Cancer Derived Brain Tumors
Resistance of ER-Positive Breast Cancer to Tamoxifen Therapy May Be Driven by APOBEC3B
RNA Mystery Solved in Triple-Negative Breast Cancer
Study Identifies Characteristics That May Increase a Breast Cancer Survivor’s Risk of Developing Leukemia Following Treatment
Study Links Body Fat, Weight Loss and Chromosome Length in Breast Cancer Patients
Taking Antidepressants with Tamoxifen Does Not Increase Breast Cancer Recurrence
Women with Luminal A Subtype of Breast Cancer Did Not Benefit From Adjuvant Chemotherapy


Study Links Body Fat, Weight Loss and Chromosome Length in Breast Cancer Patients

It is well documented that a healthy diet and exercise are key in cancer prevention and management, but the exact mechanism hasn't been clear. Now, Yale Cancer Center researchers have found an explanation in the tiny protective ends of chromosomes called telomeres. The findings were presented at the 2015 San Antonio Breast Cancer Symposium.

The researchers used a previously published Yale weight-loss intervention study called LEAN to examine how body fat and weight loss through lifestyle changes are associated with telomere length in breast cancer survivors enrolled in a weight-loss trial. Telomeres shorten with cell division and are associated with aging and increased risk of breast cancer mortality.

The Yale study – among the few to explore a link between weight loss and telomere length in breast cancer survivors – found that telomeres were slower to shorten in breast cancer survivors who lost weight through diet and exercise. In some cases, telomere shortening even reversed, said the study's first author Tara Sanft, M.D., assistant professor of medical oncology.

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