Cancer Research UK scientists in Scotland have launched a new clinical trial to find the best way to treat the chronic insomnia often experienced by cancer patients.
Over a quarter of people with cancer have severe sleep problems, which can have a devastating effect on their physical and mental well-being and their ability to cope with their disease.
Patients in the trial will be taught how to increase their chances of sleep using a technique called cognitive behavior therapy (CBT) - a type of psychotherapy that helps people examine and overcome the thoughts and behaviors at the root of their problem.
CBT has already proved to be successful in treating chronic insomnia in other situations. Now, in the largest trial of its kind, researchers will test whether the technique can help cancer patients with the condition.
Professor Colin Espie a Cancer Research UK scientist based at the University of Glasgow, says: "Chronic insomnia is not just a matter of missing one nights sleep; it can run over many consecutive nights and become a long term and distressing problem for patients.
"The condition can be triggered by depression, fears about the future, or in some cancer patients it can be a side-effect of chemotherapy.
"Sleepless nights can leave people feeling fatigued during the day and have a negative effect on their concentration and mental performance. Chronic insomnia can also be extremely frustrating for patients that are feeling tired or exhausted after chemotherapy but are unable to sleep at night."
The three-year trial, funded by Cancer Research UK, will recruit 200 patients from centers in Glasgow and Aberdeen to compare the effectiveness of CBT with the current treatment available for patients from their doctors.
Espie says: "Cognitive behavior therapy works by teaching people how to change the thoughts and behaviors that cause their insomnia. Patients will effectively learn how to re-program their body clocks so that they get good sleep at night."
Patients receiving CBT will be taught various methods to increase their chances of sleep in hour-long classes run over five weeks.
The sessions will include information about lifestyle changes, mental strategies and muscle relaxation techniques that can promote sleep.
Patients in the comparison group will receive standard treatments according to their doctor's advice.
Espie says: "Patients may be prescribed sleeping pills from their doctors for short periods of time but there is no evidence that they are effective for long-term sleep problems. Drug treatments may also cause negative side-effects and patients may become addicted to them.
"Cognitive behavior therapy has been scientifically proven to help people with chronic insomnia and we believe it will be a far more effective and healthier option for cancer patients with the condition."
Researchers will record patients' sleep patterns before and after treatment and during a six-month follow-up to see whether the new technique leads to longer and uninterrupted hours of sleep.
Lesley Walker, Director of Information at Cancer Research UK, says: "Chronic insomnia can severely diminish a person's ability to function during the day and live life to the full. It's a common but often neglected condition affecting cancer patients.
"Currently there is no ideal treatment, but we hope Professor Espie's study will provide us with the evidence to change this in the future."
SOURCE:
Cancer Research UK (http://www.cancerresearchuk.org)
