April 2004
Article Features
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Aromasin for Breast Cancer Shows Increased Disease-Free Survival
Breast Self Exam Should Not Replace Mammography
Improved Breast Cancer Survival with Clinical Trials
Estrogen Plus Progestin May Decrease Colorectal Cancer Risk
Treatment of Ductal Carcinoma in Situ Varies Widely in the United States
Physical and Emotional Well-Being Following Breast Cancer Treatment
European Marketing Approval Given for Breast Cancer Drug Faslodex
New Breast Pap Smear Detects Early Cellular Changes
Improving Breast Cancer Follow Up Visits
Tagging Faulty Breast Cancer Genes with Fluorescent Nanodots
New Imaging Technique Developed to Detect Breast Cancer
Lumpectomy and Mastectomy Provide Similar Survival Outcomes for DCIS
Breast Cancer Metastases May Share Similar Genetic Profile to Primary Tumor
More Older Women are Retaining Denser Breasts Causing Potential Screening Problems
Short-Term Hormone Replacement Therapy Safe Following Removal of Ovaries
Mastectomy Dramatically Reduces Breast Cancer Risk in Women with BRCA Mutations
Protein Inhibits Cell Growth and May Play Role in Breast Cancer
Community Breast Cancer Screening Trials Provide New Answers About Early Detection
Study Shows Womens' Self-Medication Use Higher Than Expected
Tumor Characteristics May Help Predict Survival in Breast Cancer Patients
Vaccine Targets Preneoplastic Breast Lesions
Young Breast Cancer Survivors Suffer More Long-Term After Effects


Researchers at Johns Hopkins have for the first time used a chemical marker detected by proton magnetic resonance spectroscopic imaging (MRSI) to successfully diagnose breast cancer. The diagnostic technique produces pictures of choline within breast tumors.

In the study, researchers from the Russell H. Morgan Department of Radiology and Radiological Science at Hopkins demonstrated that choline signals analyzed by MRI were significantly elevated in malignant tumors in 15 of 18 patients studied. Three of the cases could not be included because of technical failures such as patient movement or computer failure during the scanning procedure.

The results are published in the December-January issue of the Journal of Magnetic Resonance Imaging.

Scientists have long known that cancers contain elevated levels of choline, a product of membrane synthesis, but the Hopkins study is believed to be the first to demonstrate its value in accurately identifying breast tumors.

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