May 2004
Article Features
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Breast Cancer Patients with BRCA Mutations Twice as Likely to Choose Double Mastectomy
JHU Breast Evaluation Program
Unmarried Women Forego Cancer Screening
Study Finds Association Between Primary and Contralateral Breast Cancers
Race May Delay Breast Cancer Treatment
First Study of Resveratrol Dietary Supplement Finds No Effect on Breast and Prostate Cancers
Study Confirms Exercise Reduces Breast Cancer Risk in Post Menopausal Women
Annual Breast Screening May Not Be Enough for Women with Genetic Mutations
Exposure to Severn Malnutrition Associated with Increased Breast Cancer Risk
Immediate Mammogram Reading May Decrease Stress Associated with Abnormal Results
Minimally Invasive Breast Cancer Treatment Shows Promise
Chemotherapy-Induced Nausea and Vomiting Underestimated by Doctors
Clinical Trials are Needed for Older Breast Cancer Patients
Older Breast Cancer Patients Not Receiving Optimal Care
Physical Activity and Survival after Breast Cancer Diagnosis
Aiming Radar Research at Breast Cancer
Solvent and Common Drug Raise Breast Cancer Risk
Statins Do Not Increase Breast Cancer Risk
Tamoxifen Use Associated With Lower Breast Density
New Study Highlights Misunderstanding About Risks and Benefits of Tamoxifen


Angiogenesis Gene Linked to Biomarkers in Breast Cancer

Johns Hopkins Kimmel Cancer Center scientists have made what is believed to be the first link between a gene that controls blood vessel growth and increased activity in a panel of breast cancer biomarkers that regulate tumor cell growth.

Their findings were presented at the annual meeting of the American Association for Cancer Research in Orlando, Florida.

The HOXB7 (or homeobox B7) gene is thought to drive tumor development by increasing the production of growth factors that affect blood vessel development. The team of Kimmel Cancer Center researchers, led by Saraswati Sukumar, Ph.D., professor of oncology, found increased production of messenger molecules directed by the HOXB7 gene in more than 60 percent of breast cancer cell lines and 90 percent of primary breast cancers.

They also found that the gene is important in initiating cancer cells to move from their primary site to metastatic sites. Their microarray data has shown that HOXB7 gene expression is low or undetectable in normal breast tissue, and is expressed at five to seven times higher in primary tumors and up to 20 times higher in bone metastasis.

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