The breast cancer-associated antigen mammaglobin-A has been found in 80% of breast tumors but not in normal breast cells.

In a new study, T. Mohanakumar, Ph.D., of the Washington University School of Medicine in St. Louis, and colleagues demonstrate in a mouse model of human breast cancer that a mammaglobin-A cDNA vaccine reverses tumor growth in mammaglobin-A expressing breast tumors.

Writing in the Journal of the National Cancer Institute, they conclude that mammaglobin-A immunotherapy shows potential as a treatment for breast cancer.

SOURCE:
Journal of the National Cancer Institute, September 17, 2004