Current Month 2005
Article Features
  African-American Women Less Likely to Undergo Genetic Testing than White Women
Study Examines Effectiveness of Anti-Anemia Drug in Treatment of Cancer Patients
Early Stage Breast Cancer Rates are Rising as Incidence of Invasive Cases are Leveling
BI-RADS Lexicon for Ultrasound Useful for Differentiating Benign from Malignant Solid Masses
Bone SPECT Superior to FDG PET For Detecting Bone Metastases in Breast Cancer
BRCA1 Causes Ovarian Cancer Through Indirect, Biochemical Route
Breast Cancer Prevention Study for Exemestane Launched
A Big Fat Contribution to Breast Tumor Growth
Reducing Specific Gene Levels Makes Breast Cancer Cells More Responsive to Ionizing Radiation
Researchers Pinpoint Genetic Variants that Greatly Increase Breast Cancer Risk
Genetic Testing Could Bolster Radiotherapy's Effectiveness Against Cancer
Unexpected Benefit Seen in Treating HER-2 Breast Cancer with New Preoperative Drug Combo
Few Women at Risk for Breast Cancer Willing to Use Drug to Prevent the Disease
Studies Examine Menopausal Hormone Therapy and Risk of Breast Cancer Recurrence
Mother's Prenatal and Lactational Diet May Protect Daughters from Breast Cancer
NIH Panel Calls for "Demedicalization" of Menopause
Smoking While Pregnant May Increase Child's Future Cancer Risk
New Tool Can Assess Side Effects of Treatment and Prevention of Breast Cancer


Genetic Changes in Breast Tissue Caused by Pregnancy Hormone Helps Prevent Breast Cancer

A full-term pregnancy at an early age is one of the most effective ways to reduce the lifetime risk of breast cancer, according to research pathologist Irma H. Russo, M.D., of Fox Chase Cancer Center in Philadelphia. A number of studies around the world have established that a full-term pregnancy by age 20 reduces breast cancer risk by half.

Previous studies by Russo and colleagues suggest that breast cells reach full maturity - a process called differentiation - only after a full-term pregnancy. Once this process is complete, the cells are less vulnerable to cancer-causing changes. An early pregnancy confers the strongest protection by limiting the time breast cells remain immature.

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Lack of Clinical Trial Participation May Contribute to Lower Cancer Survival Rates

A new study finds poor survival rates among young adults and older adolescents with some cancers may be partially explained by the lack of participation in clinical trials. The study, published in the journal Cancer, found that age-dependent survival rates among patients with sarcomas - except Kaposi Sarcoma (KS) - correlated with clinical trial participation rates.

The authors conclude, "based on the study reported here and others in leukemias, brain tumors, and cancer in general, lack of clinical trial participation (and of the increased knowledge of tumor biology that derives from modern clinical trials) offers one explanation" for the poor cancer survival improvements in young adults.

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