Current Month 2006
Article Features
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Appetite-Inducing Hormone Receptor Found Active in Breast Cancer
Inhibiting Cell Process May Give Cancer Drug a Boost
Chemotherapy Gel May Fight Breast Cancer and Reduce Breast Deformity
Dartmouth Researchers Test New Technique to Examine Breast Tissue
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Genetic Variants and Breast Cancer Risk
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Lobular Breast Cancer Can Be Managed as Ductal Cancer
Many Breast Cancer Survivors Not Getting Recommended Mammograms
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Nanoparticles May Help Detect and Treat Breast Tumors
Number of Pregnancies Associated With Decreased Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Obesity Linked to All Types of Breast Cancer
Psycho-oncology of Breast Cancerómoving onto Survivorship
Radiation Therapy is Associated with Lower Risk of Breast Cancer Recurrence in Elderly Women
Sentinel Lymph Node Biopsy Associated with Better Quality of Life in Breast Cancer Patients
Statin Use Does Not Cause Breast Cancer
Study Finds No Link Between Breast Implants and Cancer Risk
Terahertz Imaging May Reduce Breast Cancer Surgeries
New Genetic Test for Breast Cancer
Terahertz Imaging May Reduce Breast Cancer Surgeries
Use of Estrogen by Postmenopausal Women Does Not Increase Risk of Breast Cancer
Italian Researchers Find Fenretinide Cuts the Risk of Second Breast Cancers in Young Women
Studying the Benefits of Tibetan Yoga for Women with Breast Cancer


Long-term Estrogen Therapy Linked to Breast Cancer Risk

Long-term estrogen therapy may be related to a higher risk of breast cancer among postmenopausal women who have had a hysterectomy, according to an article in the journal Archives of Internal Medicine.

Previous studies have linked the use of hormone therapy to breast cancer among postmenopausal women, but have primarily focused on the hormone combination of estrogen plus progestin, according to background information in the article. Recently released results from the Women's Health Initiative (WHI), a large clinical trial of hormone therapy, found no significant link between estrogen therapy and breast cancer in women who took the hormone for seven years.

Wendy Y. Chen, M.D., M.P.H., Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, and colleagues evaluated women who were part of the Nurses' Health Study, a group of female nurses that have been followed since 1976. In 1980, 11,508 women from the study were postmenopausal and had had a hysterectomy. Every two years the researchers enrolled all the additional women who became postmenopausal and had a hysterectomy, so 28,835 women were included by the end of the study in 2002.

Women were asked by questionnaire every two years if they used hormones and whether they had developed breast cancer. For women who developed breast cancer, the researchers obtained permission to review the women's medical records, which they used to record the hormone receptor information. Tumors were classified as positive or negative for estrogen receptor or progesterone receptor based on how they responded to specific hormonal therapies.

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