Current Month 2009
Article Features
  Breastfeeding Associated with Reduced Risk of Breast Cancer Among Women with Family History
Fatigue Related to Radiotherapy May be Caused by Inflammation
Increasing Latina Population Means Increasing Breast Cancer Rates
Kinetic Variable Most Useful for Identifying Malignant MRI-detected Breast Lesions Identified
Lifting Weights Reduces Lymphedema Symptoms Following Breast Cancer Surgery
MRI May Be Unnecessary Prior to Treatment in Most Newly-Diagnosed Breast Cancer Patients
MRI May Cause More Harm Than Good in Newly Diagnosed Early Breast Cancer
New Model Suggests Role of Low Vitamin D in Cancer Development
New Study Underway for Recurrent Chest Wall Breast Cancer
Racial Disparities in Cancer Care Reflect Hospital Resources
Studies Do Not Support Unhealthful Relation between Animal Foods and Breast Cancer
Tamoxifen Shows Promise Against Serious Infections
Targeting MMPs to Halt Advanced Metastatic Breast Cancer
Women Often Opt to Surgically Remove Their Breasts, Ovaries to Reduce Cancer Risk

Low-Dose Estrogen Shown Safe and Effective for Metastatic Breast Cancer

When estrogen-lowering drugs no longer control metastatic breast cancer, the opposite strategy might work. Raising estrogen levels benefited 30 percent of women whose metastatic breast cancer no longer responded to standard anti-estrogen treatment, according to research conducted at Washington University School of Medicine in St. Louis and collaborating institutions.

The results are reported in the Journal of the American Medical Association. Not only did estrogen treatment often stop disease progression, in some patients metastatic tumors became resensitized and again responded to anti-estrogen treatments.

"The women in the study had all experienced a relapse while on estrogen-lowering drugs, and their disease was progressing," says lead author Matthew J. Ellis, M.D., Ph.D., an oncologist with the Siteman Cancer Center at Washington University and Barnes-Jewish Hospital. "So they were faced with undergoing chemotherapy. We found that estrogen treatment stopped disease progression in many patients and was much better tolerated than chemotherapy would have been."

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