Current Month 2010
Article Features
  Acupuncture May Relieve Joint Pain Caused by Some Breast Cancer Treatments
Another Perk of Painkillers? Decreased Hormone Levels May Reduce Cancer Risk
Anti-Malarial Drug Being Studied as New Treatment for Pre-Invasive Breast Cancer
Beta-Blockers Help Reduce Metastasis and Improve Survival in Breast Cancer Patients
Bitter Melon Extract Decreased Breast Cancer Cell Growth
Common Osteoporosis Drugs Are Associated with a Decrease in Risk of Breast Cancer
Contralateral Prophylactic Mastectomy Associated with Survival in Select Breast Cancer Patients
Delaying Post-Surgical Radiation Increases Risk of Breast Cancer Recurrence in Older Women
Freezing Breast Tumors Helps Stop Cancer’s Spread in Laboratory Studies
Freezing Out Breast Cancer
Improvements Needed in Genomic Test Result Discussions
Most Early-Stage Breast Cancer Patients May Not Need Radiation After Mastectomy
Nanotechnology Tackles Major Problems Associated with Chemotherapy – Side Effects and Drug Resistance
New Studies on Surgical Options in Inherited Breast Cancer Show Drastic Treatment is Not Always Best
New Subtype of Breast Cancer Responds to Targeted Drug
New Way Discovered to Predict Which Breast Cancer Patients Should Be Treated with Anthracyclines
Palpable Breast Cancers are More Common in Women Not Undergoing Annual Mammography
Patients Requesting Prophylactic Mastectomies Overestimate Their Breast Cancer Risk
Poorer Breast Cancer Survival Associated with Micrometastases in Axillary Lymph Nodes
Pregnancy for Breast Cancer Survivors: Meta-Analysis Reveals it is Safe and Could Improve Survival
Pregnant Women Can Receive Breast Cancer Chemotherapy Without Endangering the Health of their Babies
Rare ATM Gene Mutations, Plus Radiation, May Increase Risk of a Second Breast Cancer
Specific Lymph Node Radiotherapy is Well-Tolerated after Surgery in Early Breast Cancer Patients
Studies Reveal Associations Between Pregnancy, Breastfeeding, Breast Cancer and Survival
Studies Show Huge Health Disparities Among Asian Americans, Native Hawaiians, Asian Immigrants
Study Sheds Light on How Estrogen Feeds Breast Cancer Tumors
Survival in Metastatic Breast Cancer Patients is Improving: Targeted Therapies Have Contributed
Women With Radial Scars Should Undergo a Surgical Excision to Rule Out an Underlying Malignancy


Discovery that PARP Protein Exists in All Breast Tumors Will Help Target Chemo and Predict Response

The presence of the protein poly (ADP-ribose) polymerase (PARP) in tumors can help predict their response to chemotherapy, a German scientist told the seventh European Breast Cancer Conference (EBCC7) in Barcelona. Professor Gunter von Minckwitz, from the German Breast Group Forschungs GmBH, Neu-Isenburg, said that, contrary to the current belief that PARP is associated with a limited number of tumors, he and his team found for the first time that PARP expression exists across all breast cancer subtypes, and that such tumors were highly sensitive to chemotherapy.

von Minckwitz and his team set out to investigate the expression of PARP in various hormone receptor subtypes of early breast cancer and to evaluate whether or not it could predict a total response to chemotherapy given before surgery. "We knew that a new class of drug called PARP inhibitors were effective against aggressive types of breast cancer such as those involving BRCA mutations and triple-negative breast cancer, where the tumor does not express genes for the estrogen or progesterone receptors, or for HER2," he said. "However, we didn't understand whether the presence of PARP would predict the efficacy of these drugs. Before exploring this, we needed to understand whether PARP played any role in breast cancers, whether it was restricted to particular types of tumors, how it correlated to existing prognostic and predictive markers, and whether it could predict the efficacy of chemotherapy."

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