Current Month 2011
Article Features
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Body Fat Distribution Associated with a Higher Risk of ER-Negative Breast Cancer
Cancer Survivors Likely to Experience Pain at Some Point in Care
Depression Drug May Relieve Pain from Breast Cancer Treatment
Early Investigations Promising for Detecting Metastatic Breast Cancer Cells
Elastography Helps Identify Patients Who Need Biopsy
High Dietary Fat, Cholesterol Linked to Increased Risk of Breast Cancer
Key Information About Breast Cancer Risk and Development is Found in ‘Junk’ DNA
Math Model May Help Researchers with Stem Cell, Cancer Therapies
Most Consumers Want Predictive Tests to Learn if a Disease is in Their Future
Peptide Delivers 1-2 Punch to Breast Cancer
Potential New Target for Breast Cancer Therapy
Preoperative Breast MRI Suggests High Cancer Yield
Protein Disables p53, Drives Breast Cells Toward Cancer Transition
Quality of Life Measures in Breast Cancer Clinical Trials
Researchers Discover Genetic Predisposition for Breast, Kidney Cancers
Researchers Find Indirect Path to Attack Breast Cancer Stem Cells
Risk of Breast Cancer Recurrence May Depend on Treating Surgeon
Scientists Discover Potential Strategy to Improve Cancer Vaccines
Scientists Discover Powerful Biomarker Panel for the Early Detection of Breast Cancer
Strong Social Ties Benefit Breast Cancer Patients
Study Finds Breast Inflammation is Key to Cancer Growth
Study Identifies New Genetic Signatures of Breast Cancer Drug Resistance
Study Provides Molecular Rationale for Combining Targeted Agents to Treat Breast Cancer
Women with False-Positive Mammograms Report High Anxiety and Reduced Quality of Life


Risk of Breast Cancer Recurrence May Depend on Treating Surgeon

Ductal carcinoma in situ (DCIS), or non-invasive breast cancer, is typically treated with either breast-conserving surgery—with or without follow-up radiation—or mastectomy. The treatment choice depends on clinical factors, the treating surgeon, and patient preferences. Long-term health outcomes (disease-free survival) depend on the treatments received. According to a study published in the Journal of the National Cancer Institute, however, health outcomes also are associated with the treating surgeon.

To determine the comparative effectiveness of treatment strategies, Andrew W. Dick, Ph.D., of the RAND Corporation and colleagues conducted a retrospective study of women diagnosed with DCIS between 1985 and 2000 with as many as 18 years of follow-up. They identified the women through two large tumor registries, the Monroe County (New York) tumor registry, and the tumor registry at the Henry Ford Health System in Detroit.

The researchers collected extensive data on the patients, including the rate of ipsilateral recurrence, or recurrent breast cancer in the same breast; whether the women had been treated with mastectomy or breast conserving surgery—with or without radiation therapy; and their margin status (margin of tissue surrounding their resected tumors). They defined margins as positive (in which cancer cells extend to the edge of the resected tissue), negative (cancer cells are more than 2 millimeters away from the edge of the tissue), or close (in which cancer cells are present within two millimeters of the edge).

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