Current Month 2010
Article Features
  Breast Cancer Cells Outsmart the Immune System and Thrive
Combination Overcomes Breast Cancer Resistance to Herceptin
Combining Two Peptide Inhibitors Might Block Tumor Growth
DCIS Patients who Get Invasive Breast Cancer Have Higher Risk
Higher Volume Reduces False Positives in Screening Mammography
Hit Multiple Targets for Maximum Benefit in HER2-Positive Breast Cancer, Studies Suggest
In Tiny Fruit Flies, Researchers Identify Metabolic “Switch” That Links Normal Growth to Cancer
Investigations Show that Telomerase Inhibitor PinX1 is a Key Tumor Suppressor
New Tumor Tracking Technique for Radiotherapy Spares Healthy Tissue, Could Improve Cancer Treatment
Protein Fuels Inflammation in Pancreatic and Breast Tumors
Repeat MRI Screening for Breast Cancer Results in Fewer False Positives
Researchers Identify Protein that Protects Cancer Cells from Chemo and Radiation Therapy
Study Shows How Breast Cell Communities Organize Into Breast Tissue
Taking Tamoxifen to Prevent Breast Cancer Can Save Lives and Money
With New Method, Researchers are Able to Infer How Tumors Evolve and Spread

Tiny Gems Take Big Step Toward Battling Cancer

Chemotherapy drug resistance contributes to treatment failure in more than 90 percent of metastatic cancers. Overcoming this hurdle would significantly improve cancer survival rates.

Dean Ho, an associate professor of biomedical engineering and mechanical engineering at Northwestern University, believes a tiny carbon particle called a nanodiamond may offer an effective drug delivery solution for hard-to-treat cancers.

In studies of liver and breast cancer models in vivo, Ho and a multidisciplinary team of scientists, engineers and clinicians found that a normally lethal amount of a chemotherapy drug when bound to nanodiamonds significantly reduced the size of tumors in mice. Survival rates also increased and no toxic effects on tissues and organs were observed.

This is the first work to demonstrate the significance and translational potential of nanodiamonds in the treatment of chemotherapy-resistant cancers. The results were published in the journal Science Translational Medicine.

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