Current Month 2011
Article Features
  Breast Cancer Surgery Patients Benefit from Adding Radiation Therapy
C-Reactive Protein Levels Predict Breast Cancer Survival Rates
Cancer Survivors Canít Shake Pain, Fatigue, Insomnia, Foggy Brain
Childhood Cancer Survivors At High Risk for Multiple Tumors As They Age
Community Health Worker Interventions Improve Rates of Mammography Screening
Emerging Trends in Radiation Therapy for Women Over 70 with Early Stage Breast Cancer
Exemestane Significantly Reduces the Risk of Breast Cancer in High Risk Women
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Gamma Imaging Provides Superior Tumor Detection for Dense Breasts
Hormone Test Predicts Ovarian Function after Chemotherapy for Breast Cancer
Hypnosis/Local Anesthesia Combination During Surgery Helps Patients, Reduces Hospital Stays
Many Advanced Breast Cancer Patients Do Not Receive Recommended Treatment
Molecular Movements Could Lead to New Way to Treat Cancer
New Breast Cancer Risk Model Quantifies the Impact of Risk Reduction
New Clues to How Cancer Spreads
New Strategy to Attack Tumor-Feeding Blood Vessels
No Tie Between PTEN and Response to Herceptin
Not All Breast Tumor Cells Are Created Equal; How to Target the Bad Guys
Obesity Raises Breast Cancer Survivorsí Risk of Dying of the Cancer
Reducing a Severe Side Effect of a Common Anticancer Drug
Removal of a Tiny RNA Molecule Can Inhibit Cancer Growth
Report Finds Continued Progress in Reducing Cancer Mortality
Researchers Identify New Breast Cancer Tumor Suppressor and How It Works
Researchers Study Anticancer Effect of Mushrooms
Roadmap Published for Dynamic Mapping of Estrogen Signaling in Breast Cancer
Scale Helps to Measure the Utility of Genetic Counseling in Tackling Fear of Cancer
Scientists Find Crucial Molecule Involved in Spread of Breast Cancer
Signaling Pathways Point to Vulnerability in Breast Cancer Stem Cells
Silencing a Deadly Conversation in Breast Cancer
Study Confirms Safety, Cancer-Targeting Ability of Nutrient in Broccoli
Subdivisions Reveal Effective Therapies in Triple-Negative Breast Cancer


Study Confirms Safety, Cancer-Targeting Ability of Nutrient in Broccoli

Sulforaphane, one of the primary phytochemicals in broccoli and other cruciferous vegetables that helps them prevent cancer, has been shown for the first time to selectively target and kill cancer cells while leaving normal prostate cells healthy and unaffected.

The findings, made by scientists in the Linus Pauling Institute at Oregon State University, are another important step forward for the potential use of sulforaphone in cancer prevention and treatment. Clinical prevention trials are already under way for its use in these areas, particularly prostate and breast cancer.

It appears that sulforaphane, which is found at fairly high levels in broccoli, cauliflower and other cruciferous vegetables, is an inhibitor of histone deacetylase, or HDAC enzymes. HDAC inhibition is one of the more promising fields of cancer treatment and is being targeted from both a pharmaceutical and dietary approach, scientists say.

ďItís important to demonstrate that sulforaphane is safe if we propose to use it in cancer prevention or therapies,Ē said Emily Ho, a principal investigator in the Linus Pauling Institute, lead author on the study and associate professor in the OSU Department of Nutrition and Exercise Sciences.

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