Current Month 2011
Article Features
  Breast Cancer Tumor Suppressor Gene Silenced by Low O2
Breast Density Tied to Specific Types of Breast Cancer
Childbearing May Increase Risk of Hormone Receptor-Negative Breast Cancer in African-American Women
Common Class of Pain Drugs Reduces Severity of Postpartum Breast Cancers
Computer-Aided Detection Does Not Improve Mammogram Accuracy
Detecting Occult Metastases in Lymph Nodes Not Associated with Overall Survival in Breast Cancer
Divided Appeals Court Rules on BRCA Case
Higher Estrogen Production in the Breast Could Confer Greater Cancer Risk Than Thought
Human Breast Tumor Evasion of the Antitumor Immune Response
Identification of Genes Required to Suppress Tumor Transformation in Triple Negative Breast Cancer
In Utero Exposure to Dietary Methyl Nutrients and Breast Cancer Risk in Offspring
Malignant Stem Cells May Explain Why Some Breast Cancers Develop and Recur
Maternal Consumption of Omega 3 Fatty Acids to Reduce Breast Cancer Risk in Offspring
PET Scans Confirm Effectiveness of Estrogen-Blocking Drugs in Breast Cancer Patients
Progressive Telomere Shortening Characterizes Familial Breast Cancer Patients
Researchers Discover How Some Breast Cancers Alter Their Sensitivity to Estrogen
Scientists Developing New Therapy for HER2-Positive Breast Cancer
Selectively Targeted Therapeutics for Breast Cancer
Therapeutic Eradication of DCIS Progenitor Cells
Thermally Targeted Delivery of a c-Myc Inhibitory Peptide in Vivo Using Elastin-like Polypeptide
Toward Understanding Genetic Susceptibility for Breast Cancer in Women of African Ancestry
Trastuzumab Raises Risk of Heart Problems in the Elderly with History of Heart Disease or Diabetes
Using a 'Systems Biology' Approach to Look Under the Hood of an Aggressive Form of Breast Cancer
Vitamin D and Breast Cancer in African-American and European-American Women
What Do Young Adult Daughters of BRCA Mutation Carriers Know About Hereditary Risk and How Much Do They Worry

In Utero Exposure to Dietary Methyl Nutrients and Breast Cancer Risk in Offspring

Links are being drawn to complete mammary gland development of the mother during pregnancy and reduction in breast cancer risk in her daughters. Supplementing the mother's diet with lipotropic nutrients (methionine, choline, folate and vitamin B12) is thought to increase methyl metabolism which stimulates the full development of the mammary gland, thereby inducing an epigenetic imprint in the mammary gland of the fetus and decreasing its breast cancer risk. Investigators at North Dakota State University are researching this link with the overall objective of determining the extent to which supplementing diets with methyl nutrients during pregnancy reduces the offspring's overall breast cancer susceptibility.

The study looked at 45 pregnant rats and randomized them into two groups: one to receive a control and the other to be fed a methyl-supplemented diet. Once the pups were born, they were separated into three additional groups depending on the feeding regime of their mother. When the female pups reached a specific age, they were exposed to a chemical that induced breast cancer and researchers charted when the first tumor appeared and measured all tumor sizes and volumes. Results demonstrated that the offspring from the methyl-supplemented diet group showed a decrease in tumor incidence and growth when compared to the control group. Also, they had fewer tumors and fewer tumors that multiplied.

"The conclusions of this study suggest that we may be able to prevent the development of breast cancer in daughters of women at risk for breast cancer by supplementing the mother's diet during pregnancy," said Dr. Chung Park. "We look forward to exploring this study further to strengthen the implications of these initial findings."

Era of Hope Breast Cancer Conference, Department of Defense Breast Cancer Research Program, August 2-5, 2011, Orlando, FL

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