Current Month 2011
Article Features
  Advanced Post-Mastectomy Breast Reconstruction Improves Women’s Psychosocial and Sexual Well-Being
Association Found Between Stress and Breast Cancer Aggressiveness
Bone Drug is Mixed Blessing for Breast Cancer Patients
Breast Cancer Tumor Makeup Changes Through the Course of the Disease
Breast Tenderness in Women Getting Combo Hormone Therapy Associated with Increase in Breast Density
Discovery May Predict Probability of Breast Cancer Metastasis
Discovery of Cell Mechanism That Reduces the Effectiveness of Radiation
Elderly Breast Cancer Patients Risk Treatment Discrimination
Elevated Hormone Levels Add Up to Increased Breast Cancer Risk
False-Positive Recalls Part of the Process for Annual Mammography Screenings
High-Risk, Underserved Women Benefit from MRI Screening for Breast Cancer
Higher Incidence of Secondary Breast Cancer Seen Among Black Women Regardless of Age
New Hope for Advanced Post-Menopausal Breast Cancer Patients Resistant to Hormonal Therapy
New Potential Therapeutic Target for Breast Cancer
Phase II Study Shows New Cancer Drug Combination Significantly Delays Breast Cancer Progression
Preventing Cancer Development Inside the Cell Cycle
Probability Model Estimates Proportion of Women Who Survive Breast Cancer Detected Through Screening
Protein Family Key to Aging, Cancer
Protein That Fuels Lethal Breast Cancer Growth Emerges as Potential New Drug Target
Radiotherapy Between or During Chemotherapy Cycles Reduces Risk of Breast Cancer Recurrence
Report Finds Burden of Breast Cancer Deaths Shifts to Poor
Researchers Discover That Same Gene Has Opposite Effects in Prostate, Breast Cancers
Survival Increased in Early Stage Breast Cancer after Treatment with Herceptin and Chemo
Test Could Detect Breast Cancers Earlier in Young, High-Risk, African-American Women
Women Exposed to Diethylstilbestrol in the Womb Face Increased Cancer Risk
Women in Rural Areas More Likely to be Diagnosed with Most Serious Form of Breast Cancer


False-Positive Recalls Part of the Process for Annual Mammography Screenings

Mammography screening has been shown to reduce deaths from breast cancer, but controversy remains about the best time to begin screening and how often to get screened. In 2009, the U.S. Preventative Services Task Force recommended that the decision to start regular mammography before the age of 50 years should be an individual one and that physicians should take patient context into account, including the patient's values regarding specific benefits and harms. The Task Force also recommended that women aged 50 to 74 years and younger women who opted for screening should have screening once every two years versus every year.

A potential harm of shorter interval breast cancer screening is the risk of false-positive results. To compare the cumulative probability of false-positive results and stage of cancer diagnosis after 10 years of screening with either an annual or a biennial schedule, researchers studied seven mammography registries in the Breast Cancer Surveillance Consortium, the most comprehensive breast cancer registry in the world. The researchers concluded that after 10 years of annual screening, more than half of women will have at least one false-positive recall, and 7 to 9 percent will have a false-positive biopsy recommendation. Biennial screening reduces false-positive recalls by about one-third, but is associated with a small increase in the probability of late-stage cancer diagnosis.

Using data from the same registry, researchers studied screening records for women aged 40 to 79 who underwent digital (n=213,034) versus film-screen mammography (n=638,252) to determine if one method was better than the other at detecting cancer. The researchers found that digital and film-screen mammography were equally effective for women age 50 to 79, but for women age 40 to 49—especially those with dense breasts—digital was a bit more likely to find a cancer. However there was also had an increased risk for false positive results for these younger women.

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