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Article Features
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Blocking DNA: HDAC Inhibitor Targets Triple-Negative Breast Cancer
Breast Cancer Clinical Trial Tests Combo of Heat Shock Protein Inhibitor and Hormonal Therapy
Breast Cancer Stem Cell Revealed
Breast MRI Helps Predict Chemotherapy’s Effectiveness
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Discovery Suggests New Combination Therapy Strategy for Basal-Like Breast Cancers
FDA-Approved Drug Makes Established Cancer Vaccine Work Better
Genetic Predictor of Breast Cancer Response to Chemotherapy
Heparin-like Compounds Inhibit Breast Cancer Metastasis to the Bone
Hybrid Vaccine Demonstrates Potential to Prevent Breast Cancer Recurrence
Knowing Genetic Makeup May Not Significantly Improve Disease Risk Prediction
Miniaturized Biochip Investigates the Effect of Drugs on Cancer Stem Cells
Molecule Found That Inhibits Estrogen, Key Risk Factor for Endometrial and Breast Cancers
Mystery of the Missing Breast Cancer Genes
Patients See Benefits and Risks to Direct-to-Consumer Genetic Tests
Physical Activity Linked to Reduced Mortality in Breast and Colon Cancer Patients
Researchers Create New Anti-Cancer Drug
Researchers Discover Drug Thioridazine Destroys Human Cancer Stem Cells But Not Healthy Ones
Scientists Discover Marker to Identify, Attack Breast Cancer Stem Cells
Skp2 Activates Cancer-Promoting, Glucose-Processing Akt
Study Examines BI-RADS and MRI in Predicting Breast Cancer
Study Finds Moderate Weight Loss Reduces Levels of Sex Hormones Linked to Breast Cancer Risk
Study Finds that Natural Substance Called Apigenin Slows Progression of a Human Cancer
Untangling the Development of Breast Cancer

Study Finds Moderate Weight Loss Reduces Levels of Sex Hormones Linked to Breast Cancer Risk

Even a moderate amount of weight loss can significantly reduce levels of circulating estrogens that are associated with an increased risk of breast cancer, according to a study by researchers at Fred Hutchinson Cancer Research Center – the first randomized, controlled clinical trial to test the effects of weight loss on sex hormones in overweight and obese postmenopausal women, a group at elevated risk for breast cancer.

The findings by Anne McTiernan, M.D., Ph.D., and colleagues were published in the Journal of Clinical Oncology.

"Based on previous research, our results suggest that losing just 5 percent or more of one's weight could cut by a quarter to a half the risk for the most common, estrogen-sensitive breast cancers," said McTiernan, director of the Hutchinson Center's Prevention Center and a member of its Public Health Sciences Division. McTiernan cautions that these findings only apply to overweight or obese women who are not taking hormone-replacement therapy.

Epidemiologists have long noted a link between obesity and increased risk of postmenopausal breast cancer. A relationship between body fat and estrogen production is thought to contribute to this risk.

The study was based on data from 439 overweight-to-obese, sedentary, Seattle-area women, ages 50 to 75, who were randomly assigned to one of four groups: exercise only (mainly brisk walking), diet only, exercise plus diet and no intervention. At the end of the study, participants on the diet-only and diet-plus-exercise arms lost an average of 10 percent of their starting weight, which was the goal of the intervention.

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