Current Month 2011
Article Features
  An Epigenetic Difference in Twins Could Explain the Different Risk of Breast Cancer
Blood Hormone Levels Predicted Long-Term Breast Cancer Risk for Postmenopausal Women
Breakthrough Technique Images Breast Tumors in 3-D with Great Clarity, Reduced Radiation
Breast Cancer Cells Enticed To Spread By "Tumorous Environment" As Well As Genetic Changes
Breast Cancer Scans Possible with a 25 Times Reduced Radiation Dose
Discovery Reveals Important Clues to Cancer Metastasis
Exercise and Complete Decongestive Therapy Best Ways to Manage Lymphedema
Gene Polymorphisms Identified That Are Responsible for Breast Density and Cancer Risk
High Levels of Hormones During Pregnancy Associated with Higher Risk for HR-Negative Breast Cancer
Hormone Level Linked with Increased Risk of Diabetes, Cardiovascular Disease, Breast Cancer, Death
Lactation Protein Suppresses Tumors and Metastasis in Breast Cancer
Mechanisms of Action for Green Tea Extract in Breast Cancer Prevention Identified
New Study Sheds Light on the Progression and Invasiveness of Ductal Breast Cancer
Older Breast Cancer Patients See More Complications with Brachytherapy
Patient Navigation Benefits Timely Cancer Diagnosis, Care for Vulnerable Patients
Progress in Ultrasound-Guided Surgery May Improve Breast Cancer Treatment
Promising Microspectroscopy Technique May Predict Metastasis in Breast Cancer
Study Finds Vegetable-Derived Compound Effective in Treating Triple-Negative Breast Cancer
Study Shows Breastfeeding Reduced Risk for ER/PR-Negative Breast Cancer
Study Suggests How Expanding Waistlines May Contribute to Cancer
Targeting Cancers’ “Addiction” to Cell-Cycle Proteins Shuts Down Tumors in Mice
Task Force Recommends Against Hormone Replacement Therapy for Postmenopausal Women
The Complex Association Between Moderate Alcohol Consumption and Breast Cancer


Hormone Level Linked with Increased Risk of Diabetes, Cardiovascular Disease, Breast Cancer, Death

Plasma levels of proneurotensin are associated with the development of diabetes, cardiovascular disease, cardiovascular and total mortality, and breast cancer in women during long-term follow-up, according to a study in the Journal of the American Medical Association.

Neurotensin, an amino acid peptide primarily expressed in the central nervous system and gastrointestinal tract, regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans, according to background information in the article. Proneurotensin is a precursor of the hormone neurotensin.

Olle Melander, M.D., Ph.D., of Lund University, Malmo, Sweden and colleagues conducted a study to test if a fasting plasma concentration of proneurotensin is associated with future risk of diabetes mellitus, cardiovascular disease, breast cancer, and death. Proneurotensin was measured in plasma from 4,632 fasting participants of the population-based Malmo Diet and Cancer Study baseline examination 1991-1994. Various models were used to evaluate the relationship between baseline proneurotensin and first events and death during long-term follow-up until January 2009, with median (midpoint) follow-up ranging from 13.2 to 15.7 years depending on the disease.

Overall, proneurotensin was related to risk of new diabetes, cardiovascular disease, and cardiovascular mortality, with a significant interaction between proneurotensin and sex on risk of cardiovascular disease. "Exclusively in women, proneurotensin was related to incident diabetes, cardiovascular disease, breast cancer, total mortality, and cardiovascular mortality," the authors write.

Read More of the Main Article

 
Visit the Ezine


Visit the BreastCenter

Visit the Quality Corner
Avon Breast Cancer Crusade - AVON the company for women

  This website is supported in part by an unrestricted educational grant provided by Avon