Current Month 2011
Article Features
  Ability to Metabolize Tamoxifen Affects Breast Cancer Outcomes
Breast Cancer Cells Growing in 3D-Matrix Revert to Normal
Breast Cancer Cells Interact with Non-Cancerous Tissue to Drive Metastasis
Changes in Progenitor Cell Population in Breast May Be Overlooked Factor in Breast Cancer
Delaying Childbirth May Reduce Risk of an Aggressive Form of Breast Cancer
Existing Drugs May Help More Breast Cancer Patients
Genes Identified That Predict Whether Trastuzumab Will Work for Breast Cancer Patients
Genomic Sequencing Reveals Drug Targets for Triple-Negative Breast Cancer
HER2-Positive Stem Cells Found in HER2-Negative Breast Cancer
miR-205 Can Be Responsible for Breast Cancer
New Hormone Therapy Shows Promise for Menopausal Symptoms in Animal Model
New Small Molecule Inhibitor Could Be a Safe and First-Line Treatment for Metastatic Breast Cancer
Obesity and Overeating During Menopause Together Promote Breast Tumor Growth and Progression
Protein Tied to Cancer-Drug Resistance in Mice
Researchers Develop Novel 3-D Culture System for Inflammatory Breast Cancer
Researchers Discover New Molecule Linked to Late Stage Breast Cancer
Researchers Identify Two New Genetic Mutations Associated with Cowden Syndrome
Study Compares Eribulin vs. Capecitabine for Women Whose Breast Cancer Has Spread
Study Finds Diverse Genetic Alterations in Triple-Negative Breast Cancers
Study Uncovers Mechanism Used by BRCA1 to Suppress Tumors
To Fight Metastatic Breast Cancer, Resistance Must Be Broken
Transcription Factor Could Influence Future Breast Cancer Treatment
Understanding Cell Organization to Tackle Cancer
US Cancer Screening Rates Decline Over the Last 10 Years
Women with Higher Carotenoid Levels Have Reduced Risk of Breast Cancer

Obesity and Overeating During Menopause Together Promote Breast Tumor Growth and Progression

Obese women might be able to eliminate their increased risk for postmenopausal breast cancer by taking measures during perimenopause to prevent weight gain and to therapeutically control the metabolic effects of their obesity, according to the results of a preclinical study published in the journal Cancer Research.

"Obese postmenopausal women have increased risk for breast cancer and poorer clinical outcomes compared with postmenopausal women who are lean," said Paul S. MacLean, Ph.D., associate professor of medicine at the University of Colorado Anschutz Health and Wellness Center in Aurora, Colo. "The reasons for this are not fully understood.

"Unfortunately you cannot do the studies needed to address this issue in humans. So, we merged rat models of obesity, breast cancer and menopause to best mimic the events that link premenopausal obesity to an increased rate of postmenopausal breast cancer."

During menopause, women often gain weight because they consume more food than their body needs. In a previous study, MacLean and colleagues used their rat model to show that weight gain following surgical ovariectomy, which models menopause, helped promote breast tumor development in obese rats.

Read More of the Main Article

Visit the Ezine

Visit the BreastCenter

Visit the Quality Corner
Avon Breast Cancer Crusade - AVON the company for women

  This website is supported in part by an unrestricted educational grant provided by Avon