Current Month 2013
Article Features
  A Third of Women Might Benefit From More Frequent Mammograms
Adjuvant Chemotherapy Increases Markers of Molecular Aging in the Blood of Breast Cancer Survivors
Breast Cancer Gene Could Play Critical Role in Obesity and Diabetes
Catching the Early Spread of Breast Cancer
Deaths From Breast Cancer Fall in Europe
Discovery Signals New Treatment for Those at High Risk of Breast and Ovarian Cancer
Faster Genetic Testing Method Will Likely Transform Care for Patients with Breast Cancer
Gene Implicated in Progression and Relapse of Triple Negative Breast Cancer
Genetic Testing May Help Select Women with ER+ Breast Cancer For Extended Hormone Therapy
Mechanical Forces Driving Breast Cancer Lead to Key Molecular Discovery
Obesity and Diabetes Have Adverse Effects on Cancer Outcomes
Peaches Inhibit Breast Cancer Metastasis in Mice
Radiotherapy after Mastectomy Benefits Women with Breast Cancer in 1-3 Lymph Nodes
Regular Physical Activity Reduces Breast Cancer Risk Irrespective of Age
Researchers Destroy Cancer with Cryoablation and Nanoparticle-Encapolated Anticancer Drug
Researchers Issue State-of-the-State on Genetic-Based Testing and Treatment for Breast Cancer
Some Breast Cancer Tumors Hijack Patient Epigenetic Machinery to Evade Drug Therapy
Twenty-Five Percent of Breast Cancer Survivors Report Financial Decline Due To Treatment
Using Big Data to Identify Triple-Negative Breast, Oropharyngeal, and Lung Cancers
'Velcro Protein' Found to Play Surprising Role in Cell Migration
Where Are We With Breast Cancer In 2013?
Y-90 Provides New, Safe Treatment for Metastatic Breast Cancer

Breast Cancer Gene Could Play Critical Role in Obesity and Diabetes

The gene known to be associated with breast cancer susceptibility, BRCA 1, plays a critical role in the normal metabolic function of skeletal muscle, according to a new study led by University of Maryland School of Public Health researchers. Dr. Espen Spangenburg, associate professor of kinesiology, and his laboratory team are the first to identify that the BRCA1 protein is expressed in the skeletal muscle of both mice and humans, and that it plays a key role in fat storage, insulin response and mitochondrial function in skeletal muscle cells. The research is published in the Journal of Lipid Research.

"Our findings suggest that certain mutations in the BRCA1 gene may put people at increased risk for metabolic diseases like obesity and type 2 diabetes," said Spangenburg. "Without BRCA1, muscle cells store excess fat and start to look diabetic. We believe that the significance of the BRCA1 gene goes well beyond breast cancer risk."

Spangenburg and colleagues, including researchers from the University of Maryland School of Medicine, Brigham Young University, Karolinska Institutet in Sweden, and East Carolina University, found that the BRCA1 protein exists in both mouse and in human skeletal muscle. This is the first evidence since the discovery of BRCA1 in 1994 that the gene is expressed in human muscle cells.

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