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Targeted Radiotherapy Limits Side Effects of Breast Cancer Treatment

Breast cancer patients who have radiotherapy targeted at the original tumor site experience fewer side effects five years after treatment than those who have whole breast radiotherapy, and their cancer is just as unlikely to return, according to trial results published in the journal The Lancet.

The Cancer Research UK-funded IMPORT LOW trial revealed that five years after treatment, almost all patients were disease free.

The researchers at 30 radiotherapy centers across the UK, led by The Institute of Cancer Research, London, and the Cancer Research UK Cambridge Centre, studied more than 2,000 women aged 50 or over who had early stage breast cancer that was at a low risk of coming back. Following breast conserving surgery, some patients were treated with whole breast radiotherapy - the clinical standard - while others received partial breast radiotherapy.

Women who received partial radiotherapy reported fewer long term changes to the appearance and feel of their breast than those who had radiotherapy to the whole breast.

Following presentation of the initial results, the UK Royal College of Radiologists 2016 breast radiotherapy consensus stated that partial breast radiotherapy could be considered for selected patients using the IMPORT LOW technique. In addition, the Danish Breast Cancer Oncology Group also adopted this partial breast radiotherapy technique for selected patients.

Dr. Charlotte Coles, Reader in Breast Radiation Oncology at Cambridge University, chief investigator for the trial and first author of the publication, said: "We started this trial because there was evidence that if someone's cancer returns, it tends to do so close to the site of the original tumor, suggesting that some women receive unnecessary radiation to the whole breast.

"Now we have evidence to support the use of less, but equally effective, radiotherapy for selected patients."

Professor Judith Bliss, scientific lead for the study within the Clinical Trials and Statistics Unit at The Institute of Cancer Research, London, said: "We're delighted that the results of this trial have the potential to lead to a real change in the way selected breast cancer patients are treated.

"The technique used here can be carried out on standard radiotherapy machines so we anticipate that these results will lead to further uptake of this treatment at centers across the country and worldwide."

Professor Arnie Purushotham, Cancer Research UK's senior clinical adviser, said: "One of the challenges when treating early stage breast cancer is trying to minimize the side effects that can have a real impact on a woman's life, without affecting the chances of curing her. This approach could spare many women significant physical discomfort and emotional distress."

SOURCES:
The Lancet, August 2, 2017
Cancer Research UK (http://www.cancerresearchuk.org)




 




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