Ask an Expert: Understanding Pathology Results

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Understanding Pathology Results
Questions explaining and understanding pathology results.
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 Asked: 8/13/2018 Immunostain for E-cadherin shows loss of membranous staining, confirming lobular phenotype.
 Asked: 8/13/2018 A second smaller tumor was discovered during my post op pathology report.
 Asked: 8/9/2018 There was a prior question regarding repeat testing of the surgical sample for estrogen markers.
 Asked: 8/1/2018 My surgical specimen for breast cancer was not rechecked for the type of breast cancer to confirm the ER, PR, HER2 status.
 Asked: 8/1/2018 what does it mean when the estrogen receptor is positive 100%, progesterone receptor is negative less than 1% and HER2 is negative.
 Asked: 7/31/2018 Final pathology report says invasive ductal carcinoma with extensive intraductal component / DCIS, both grade 2.
 Asked: 7/31/2018 Is stage 3A, IDC, ER and PR 100% and Her 2 neg, mastectomy, radiation, oophrectomy, and femara, curable? .
 Asked: 7/31/2018 NUCLEAR MEDICINE THYROID CA METS SCAN POST THERAPY IMPRESSION: 1 week post therapy with the stellate artifact at the anterior neck.
 Asked: 7/30/2018 I was recently diagnosed with invasive ducal carcinoma with squamous differentiation (metaplastic breast cancer).
 Asked: 7/30/2018 Received a copy of Mom''s pathology report today.
 Asked: 7/20/2018 I was recently diagnosed with IDC, ER+/PR+ (both over 90%) and HER2- with Ki67 of 30%.
 Asked: 7/20/2018 Pathological result -pT2N0MX.after operation my gallstones in gallbladder.
 Asked: 7/20/2018 My A/G Ratio is at 1.1 3 weeks after my second Cytoxan/Taxotere chemo treatment.
 Asked: 7/19/2018 My cancer antigen 27-29 test went from <8 to 11 after second round of chemo.
 Asked: 7/16/2018 What does extensive lymphoplasmacytic response to tumor mean.
 Asked: 7/13/2018 My daughter is 19 and she discovered two lumps in her left breast.
 Asked: 7/10/2018 Diagnosed with Invasive ductal carcinoma grade two, negative SNB, but ductal carcinoma in situ grade 2 located at new margin 1.5mm from new margin.
 Asked: 7/2/2018 I have TNBC .
 Asked: 6/29/2018 had biopsy last year, pathology: fibrosis. choose excisional for the same lump last week because of palpable hardness.
 Asked: 6/29/2018 I had a cnb last year. Pathology fibrosis.
 Asked: 6/20/2018 Hi, "My pathology report says: Breast, right, microcalcifications, stereotactic biopsy: DCIS, mircopapillary, cribriform and clinging-type with focal central necrosis, nuclear grade 2-3
 Asked: 6/19/2018 Hi Lillie, I was diagnosed with breast cancer, and my path report it is ER+ 100% and PR+ 3%, listed positive for both.
 Asked: 6/19/2018 My wife was recently diagnosed with a 6mm IDC Grade 1 tumor.
 Asked: 6/15/2018 My ultrasound results said I had an 8mm mass.
 Asked: 6/15/2018 I have heard of other people''s biopsies coming back making a note of LVI.
 Asked: 6/5/2018 My final pathology states that my left breast mastectomy contains extensive high grade DCIS with RARE, SCATTERED FOCI CONSISTENT WITH MICROINVASION.
 Asked: 6/4/2018 Tailor x intermediate study redefined risk categories (11-25) and results released today.
 Asked: 5/30/2018 what does "m" stand for on path report saying ympT1b ?
 Asked: 5/29/2018 Can I send my pathology report to Hopkins for a second opinion?
 Asked: 5/29/2018 Final Diagnosis: Right breast mass, biopsy: -duct all carcinoma in situ, solid and cribriform types -intermediate nuclear grade -negative for invasive carcinoma (calppnin and CD-10 immunoperoxidase stains performed) -Estimated...
 Asked: 5/29/2018 what do you mean by a pathological staging report ypT1cN1a where her ER-ve, PR-ve, HER2 +ve.
 Asked: 5/29/2018 Invasive Ductal Carcinoma (Nottingham score 3+3+3=(9/9), Grade 3, Fragmented Pieces Measuring 0:1 CM in Largest Dimensions What does this mean??
 Asked: 5/22/2018 What does p63 immunoreactive mean? A single antibody stain procedure for cytokeratin and an additional single antibody stain procedure for p63 are performed for evaluation...
 Asked: 5/17/2018 Dear Lillie, Does any research suggest that stereotactic biopsies can cause focal lvi or pni? Thank you!
 Asked: 5/16/2018 I was diagnosed with a 5mm IDC, stage 1a, grade 1, er positive (95%) and progesterone positive(95%), a ki-67 less than 10% and a p53...
 Asked: 5/7/2018 I was diagnosed with IDC stage 1, 1.4 cm, grade 3 breast cancer with focal and central necrosis as well as DCIS grade 3...
 Asked: 5/3/2018 Pathology report showed PT1C, PN1, PN.
 Asked: 4/26/2018 Is an estimated onco score usually pretty close to the actual score when tumor is sent for testing??
 Asked: 4/26/2018 Had a left breast mastectomy last week.
 Asked: 4/16/2018 My wife 45 years old just completed her lumpectomy iand was staged as T1N1MO ,1 A , clean margins with an indolent tumour...
 Asked: 4/16/2018 How long should I expect to wait to hear about Ki-67 results?
 Asked: 4/16/2018 My understanding is that ASCO and NCCN have different recommendations on the relevance of Oncotype DX screening results in lymph node positive cases (assuming also...
 Asked: 4/16/2018 Hello. I was diagnosed Feb 2018 with TNBC, 1 cm, stage 1, no nodes involved.
 Asked: 4/12/2018 All the charts indicate that for luminal A breast cancer (slow growing and low grade) the odds for a recurrence are more likely after 5 years.
 Asked: 4/12/2018 Please help me out My ultrasound findings say:In the retreoareolar region of the right breast along the 12 o''clock radial there is 11mm complexs space occupying...
 Asked: 4/9/2018 Options for estrogen positive, progesterone negative and her2 negative .
 Asked: 4/3/2018 my oncotype dx waa low risk at 14.
 Asked: 3/26/2018 Hi ~ I''ve been trying to find out the meaning of parts of my pathology report online to no avail.
 Asked: 3/22/2018 I had surgery to remove an enlarged palpable axillary lymph node.
 Asked: 3/22/2018 I had BMX after dose dense AC-T chemo, 2.1 cm of residual DCIS with 3 foci of micro invasions was found in the breast.
 Asked: 3/20/2018 Hi there. My lumpectomy showed multiple radial scars,columnar cell change/hyperplasia, apocrine cyts, no unequivocal atypical.
 Asked: 3/14/2018 Help with understanding diagnosis: Following an excisional biopsy left breast: Diagnosis: left Breast tissue: Biopsy site changes Fibrocystic changes, nonproliferative No evidence of atypia or malignancy
 Asked: 3/8/2018 Hi,I had a partial mastectomy and it was free of cancer but they found an area of 5cm ◊3cm◊3cm of a trabucalated scar and inflammation...
 Asked: 3/7/2018 Hello, My mo sent my pathology slides out per my request and now they are requesting the blocks.any reason why they would need them?
 Asked: 3/6/2018 What does this all mean in plain English? I have my oncology appt next week and want to go in educated.
 Asked: 3/5/2018 Hello, My breast biopsy report says Firbroednoma with myxoid changes.
 Asked: 3/5/2018 Hello and thanks for your service I am outside the USA this year & know that CTC and biomarkers arenít standard practice.
 Asked: 3/2/2018 IDC from core bx. Low grade necrosis absent, lymphovasc invasion absent, calcification absent, ER receptor - positive 100%, PR receptor positive 100% HER2 equivocal submitted for FISH, Mib-1 proliferation index intermediate.
 Asked: 3/2/2018 I was tapering off bio-identical hormones for 2 months before my surgical sample.
 Asked: 3/2/2018 I viewed your answers to another posted question 3/1/2018 regarding testing the surgical sample by hospital/clinic MD versus Genomic Health, maker of Oncotype DX for...
 Asked: 3/2/2018 what does it mean when a path report reads "ADH displays solid and cribriform growth with apocrine features and calcifications" on biopsy of micro calcification...
 Asked: 3/2/2018 I have a solid 2.5 cm breast mass.
 Asked: 3/1/2018 My surgical tissue sample was not tested for ER, PR, HER2.
 Asked: 3/1/2018 Is the doctor responsible for diagnosing and forming a treatment plan for a patient or does the patient have to make the treatment plan for...
 Asked: 2/27/2018 I have received my pathology report after a core breast biopsy.
 Asked: 2/27/2018 63 y.o. with IDC grade 1, estrogen 90% positive progesterone 80 % positive, Her-2 neg (FISH), Ki-67 9%.
 Asked: 2/26/2018 I have just found out I am cancer-free after six rounds of chemotherapy! I was estrogen and progesterone negative but HR Positive.
 Asked: 2/23/2018 My pathology after core biopsy states fibrocystic changes with fibrosis including PASH, columnar cell hyperplasia, multifocal sclerosing adenosis, apocrine metaplasia
 Asked: 2/22/2018 I am a 54 yo WF, family history of breast cancer.
 Asked: 2/22/2018 I am 1 week post bilateral mastectomy for 2.8 cm DCIS.
 Asked: 2/20/2018 Follow up question. Thank you for clarifying things for me.
 Asked: 2/19/2018 The pathology of my second lumpectomy say: Left breast, anterior margin, excision: DCIS, low nuclear grade, cribriform and micro papillary pattern with focal necrosis, largest...
 Asked: 2/19/2018 First of all thankyou for taking the time to answer my questions.
 Asked: 2/19/2018 metaplastic carcinoma. What is survival rate.
 Asked: 2/19/2018 Hi. Newly diagnosed IDC Grade 3.
 Asked: 2/15/2018 Thank you for help. Hope in correct subject area or pls move! Just had CYP etc tests (life of bad responses antidepressants, pain, migraine etc meds).
 Asked: 2/14/2018 Thank you for answering the first part of my question regarding the CYP2D6 test.
 Asked: 2/13/2018 In August I will be 5 year survivor for stage 1 breast cancer.
 Asked: 2/11/2018 1. Left breast, excision with wire-guided localization: Invasive ductal carcinoma, Nottingham combined histologic grade 1 (tubules 2, nuclei 2, mitoses 1) Two foci of invasive carcinoma identified, largest focus measures 2.5cm in greatest dimension.
 Asked: 2/8/2018 I am having a breast biopsy for an indeterminate palpable breast mass confirmed by diagnostic mammogram and ultrasound.
 Asked: 2/2/2018 Two masses in the same breast: #1 Invasive moderately differentiated duct carcinoma 3 mm mass #2 Invasive poorly differentiated duct carcinoma with focal necrosis and calcifications 1.3...
 Asked: 2/1/2018 If your biopsy shows both Lobular and Ductal Atypical cells, and lumpectomy removes these cells-does your risk of developing breast cancer decrease? Or do...
 Asked: 1/31/2018 If additional tumors are found by surgical sample after a core biopsy should the specimen and each tumor be tested again for Estrogen, progesterone and...
 Asked: 1/29/2018 Hi Lillie. Is a her2- tumor less aggressive than a her2+ one? I know grade tells how aggressive a tumor is.
 Asked: 1/30/2018 I was diagnosed with ER/PR negative, HER2+ breast cancer, Stage 3 with 5 nodes postive and a 6mm tumor.
 Asked: 1/28/2018 What are the implications/significance if lymphovascular invasion is identified? Does it affect treatment recommendation? Risk of recurrence? .
 Asked: 1/26/2018 Can you explain Ki67, how it is used and if it is important since itís Considered difficult to use without consistent methodology in pathology?
 Asked: 1/26/2018 Can you please explain an "Equivacol" HER2 result? IHC 2+ and FISH heterogeneity of HER2/neu gene amplification .
 Asked: 1/26/2018 I received standard treatment for TNBC. Neoadjuvant ac+t, surgery and radiation.
 Asked: 1/26/2018 "no lymphovascular invasion identified" yet 1/5 nodes (SLNB) positive, how did cancer cell(s) travel to node? What is the significance/importance of no lymphovascular involvement...
 Asked: 1/25/2018 My 1/23 question w/pathology results relates to concern re metastasis/survival as a recent ''Ask an Expert'' answer was 99% 5-yr.
 Asked: 1/24/2018 Lumpectomy, IDC w/tubulur features, 16mm tumor "no lymphovascular invasion identified", ki67 1-2% but 1/5 nodes (SLNB) had macrometasis of 2.1mm.
 Asked: 1/24/2018 Are there non-invasive ways to diagnose cancer cells in lymph nodes without all the damaging surgery in the axilla? It seems like this would be...
 Asked: 1/22/2018 WHAT DOES KI-67{< OR = 20% -SAYS FAVORABLE ---THEN UNDER UNFAVORAGLE SAYS kI-67>40%} AND ALSO WHAT IS HER-2/NEU- favorable 0 or 1+---BORDERLINE 2+---AND unfavorable...
 Asked: 1/18/2018 What does it mean ER diffusely positive, CK 5/6 focally absent and p63 retained around ducts? Thanks..
 Asked: 1/16/2018 What does a Ki-67 score of 5.8 mean?
 Asked: 1/16/2018 How do cancer cells get to the axillary lymph nodes? What method of transport do they use to get there? Blood? Lymph...
 Asked: 1/12/2018 I have been diagnosed with a reocurring of dcis-stage o agai and non invasive-in the same area as 2016.
 Asked: 1/10/2018 what is well differentiated invasive ductal carcinoma with calcifications (tubule formation 2/3, nuclear pleomorphism 2/3, mitotic counts 1/3), measuring 1.3 cm in maximal

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