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Understanding Pathology Results
Questions explaining and understanding pathology results.
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 Asked: 1/31/2015 Is a Magee score of 20 equivalent to an Oncotype DX score of 20? Does a Magee score of 20 mean that there is...
 Asked: 1/28/2015 Please see summary of histology below. Should Lymph nodes also be investigated? Is radiotherapy advised? Do I have cancer? Thank you very much! Mandi Bouwer SUMMARY LUMPECTOMY: TUMOUR LOCATION: Left breast TUMOUR QUADRANT: supero-lateral TUMOUR SIZE: Macroscopic: 6 mm Microscopic (on immunohistochemical marker): 4.5 x 3.5 mm TUMOUR TYPE: Invasive lobular carcinoma - Tubulolobular type GRADE: Not applicable EXTENT OF INVASION: Primary tumour (pT) pT1a: Tumour more than 0,1 cm but not more than 0,5 cm in greatest dimension REGIONAL LYMPH NODES (pN): pNX: Cannot be assessed (previously removed or not removed for pathologic study) RESECTION MARGINS OF INVASIVE TUMOUR: Marginal CLOSEST RESECTION MARGIN: 1 mm anterior DISTANCE FROM DEEP FASCIA: Cannot be assessed NIPPLE: Cannot be assessed SKIN INFILTRATION: Cannot be assessed LYMPHOVASCULAR INFILTRATION: Absent PERINEURAL INFILTRATION: Absent MULTIFOCAL (MORE THAN ONE QUADRANT) Cannot be assessed RECEPTORS: Oestrogen receptors - to follow Progesterone receptors - to follow c-erbB-2 - to follow CARCINOMA IN-SITU: Carcinoma in situ present TYPE: Atypical lobular hyperplasia and lobular carcinoma in-situ LOBULAR CARCINOMA IN SITU: % of whole tumour represented by carcinoma in situ: >20% RESECTION MARGINS OF CARCINOMA IN SITU: Marginal 1.5 mm REST OF BREAST: Fibrocystic change AXILLARY DISSECTION: Not done Immunohistochemical markers: Oestrogen receptor - 2+ positive in 80% of tumour cells. Progesterone receptor - 3+ positive in 50% of tumour cells. HER-2 - negative COMMENT: A small invasive tubulolobular carcinoma is present with a larger component of atypical lobular hyperplasia and lobular carcinoma in-situ (pT1a).
 Asked: 1/26/2015 I''m 48 years old. had a lumpectomy and SNB, 1/3 nodes was positive and margins were close.
 Asked: 1/24/2015 5 years ago I had atypical papilloma and atypical columnar cells removed near nipple on same breast.
 Asked: 1/23/2015 sterotactic biopsy of microcalcifications path report shows flat epithelial atypia, columnar cell change, microcysts, stromal fibrosis, hyalinized fibroadenomatoid change
 Asked: 1/22/2015 57 years old, ductal carcinoma in situ, invasive ductal, 0.8 cm lumpectomy, clear margins, Her2 negative, two lymph nodes removed, SLNB, results both were negative
 Asked: 1/22/2015 Age 61 found lump 2-3 0''clock left breast needle core bipsy 12mm on ultrasoujd, only 8m on core biopsy, hist grade 2 IDC, no definite...
 Asked: 1/22/2015 Thank you for answering my question about the one close margin reported in my pathology report after lumpectomy.
 Asked: 1/23/2015 What does a Magee score of 20 mean?
 Asked: 1/21/2015 What does invasive matrix producing ductal carcinoma moderately differentiated (Nottingham grade 2) mean???
 Asked: 1/23/2015 Hi! My radiology report states the following: The neoplastic cells are positive for CD31 and CD34.
 Asked: 1/21/2015 Margins: I got my pathology today after my lumpectomy for what had been diagnosed, after stereotactic biopsy, as Grade 3 DCIS.
 Asked: 1/21/2015 I had an ultrasound done after finding 2 lumps, one in and one above my right breast.
 Asked: 1/20/2015 Hi, I was diagnosed and had surgery for papilloma in my right breast in November.
 Asked: 1/18/2015 I underwent lumpectomy, 10/22 lymph node + HER 2+ in February 2014, followed by 6 rounds of chemo concurrent (and still on) Herceptin, 33 radiation...
 Asked: 1/18/2015 I''m over 2 years out from treatment for Stage III TNBC.
 Asked: 1/17/2015 Hi.
 Asked: 1/15/2015 Hi Iím having a hard time understanding these results from my vacuum assisted biopsy.
 Asked: 1/15/2015 Hello i had a lumpectomy on left breast and a palpable mass removed on right: results or confusing.
 Asked: 1/15/2015 Hi - I have a strong family history of breast cancer.
 Asked: 1/14/2015 I had an ultra sound guided biopsy and my doctor told me that the results were that I have an atypical papilloma.
 Asked: 1/14/2015 All things being equal, is it better to,have a grade 2 or grade 3 tumor? Is it true grade 3 will respond better to chemo...
 Asked: 1/14/2015 Hello, I am a 54 y/o white female.
 Asked: 1/14/2015 I had my first mammogram in November.
 Asked: 1/9/2015 I will consider JH for second opinion considering what is said with general surgeon on appointment next week.
 Asked: 1/9/2015 I had breast reduction surgery Oct. 31pathology report states I have atypical ductal hyperplasia.
 Asked: 1/9/2015 Hi, my mother in law (60 y/o white) is dx''ed with: Poorly differentiated infiltrating ductal carcinoma with tumor necrosis. I am a dietitian so aware that poorly...
 Asked: 1/8/2015 Hi Thanks for your previous response since you were not able to connect my first post to the second one I combine them as follow. My...
 Asked: 1/7/2015 Thanks so much for your respond. If you remember my mom is 72 and I posted her pathology lab result, I just got her second result as follow: ER: Positive 95% PR:Positive 95% HER-2 Eqivocal (2+) Ki67: 10% My mom said she a scan done before her surgery and her other organs were fine.
 Asked: 1/5/2015 Hi, my mom (72 yrs) is out of state and I am worried and need help to know what is the best treatment option for her.
 Asked: 1/4/2015 Pathology came back with a report of focal rare ducts partially involved with early atypical ductal hyperplasia (ADH), intraductal papillomatosis, florid ductal hyperplasia, multiple cycts,...
 Asked: 1/2/2015 How much weight or predictive reliability can be given to an oncotypedx score for dcis? Thanks for your wonderful service!
 Asked: 1/2/2015 path: (1) a single focus of microinvasion of DCIS, intermediate nuclear grade, solid and cribriform types, with associated microcalcifications.
 Asked: 1/1/2015 How do yo determine tumor size when biopsy site is 1.7 x 1.7 x 1.5 cm with 0.3cm from the closed inked lateral margin when...
 Asked: 1/1/2015 What stage is this? I got my stereotactic biopsy last week.
 Asked: 12/28/2014 I recently had a breast biopsy and the pathology was DCIS nuclear grade 3 with solid and cribriform and comedonecrosis.
 Asked: 12/27/2014 "Invasive carcinoma, favor pleomorphic lobular, histologic grade 3 and nuclear grade 3." What does it mean??pls help.I''m worried abt my mom!
 Asked: 12/26/2014 What does positive 1+ staining in 2-3% of nuclei and negative 1+ staining in less than 1% of nuclei mean?
 Asked: 12/24/2014 I have a biopsy report which says Ductal carcinoma in-situ grade II with few foci suspicious of invasion My doctor wants to do a lumpectomy and a...
 Asked: 12/23/2014 Thank you for answering my previous question regarding the mucinous cancer.
 Asked: 12/22/2014 My HER2 status came back equivocal on IHC and FISH.
 Asked: 12/22/2014 First off'' I want to thank you for what you do.
 Asked: 12/22/2014 I was diagnosed with right breast Stage 1 Grade 2 T1b (9mm) N0 (0/) M0 invasive micropappilary cancer with lymphovascular invasion and Grade 2 DCIS.
 Asked: 12/21/2014 I was dx. with IDC, Stage II, grade 2 via core biopsy.
 Asked: 12/21/2014 I have read where if you have micropapillary patterns present in your invasive ductal carcinoma that recurrence rates are high even if mastectomy was done
 Asked: 12/19/2014 I was diagnosed with intraductal papillomata with calcifications and intraductal papilloma with rare calcifications.
 Asked: 12/18/2014 I was diagnosed with a complex sclerosing lesion with micro calcifications measuring 22mmx16mmx13mm after MRI guided core needle biopsy on 12/10.
 Asked: 12/16/2014 Follow up to your reply on 12/15.
 Asked: 12/15/2014 I have been diagnosed with 1cm cancer ER+, PR weakly positive, HER 2 negative and Ki- 67 58%. Original recommended treatment was lumpectomy, radiation, anti hormonal...
 Asked: 12/15/2014 I had an ultrasound-guided core needle biopsy performed a week ago.
 Asked: 12/15/2014 Hello I got my biopsy back The doctor said I had microcalcifications.
 Asked: 12/12/2014 Microscopic examination of a FNA indicated: 1) A few papillary structures.
 Asked: 12/12/2014 Results from second surgery to clear one margin: "No residual invasive carcinoma is identified.
 Asked: 12/11/2014 My Wife had an aspiration performed which resulted in the following description: - "a few Papillary structures - "large clusters of epithelial cells" - "coarse chromatin" - "Some nuclei...
 Asked: 12/8/2014 My core needle biopsy just say''s Proliferative Fibrocystic Changes that''s it.
 Asked: 12/7/2014 Just revisiting the question I asked a couple days ago.
 Asked: 12/6/2014 I''m very concerned that LVI was found on one slide.
 Asked: 12/6/2014 I am 59 years old. My ki67 score is 7% (low) and mitotic rate was a 1.
 Asked: 12/6/2014 Another poster says that Oncotype DX does not work on LVI? Is that true? In another post you said the test is used on node positive patients.
 Asked: 12/6/2014 Hi, I am just beginning what feels like an already long process of being diagnosed.
 Asked: 12/5/2014 Hi Lillie.
 Asked: 12/4/2014 I wrote the following last night: " I am revisiting a question I posted last week.
 Asked: 12/4/2014 I am revisiting a question I posted last week.
 Asked: 12/3/2014 The results from my biopsy (as read to me over the phone) came back as DCIS, nuclear grade 2-3 cribriform and solid pattern with focal...
 Asked: 12/3/2014 Core biopsy done and no hx of mastitis no trauma or injury to area path report says acute chronic mastitis and fat necrosis ...
 Asked: 12/2/2014 My doctor performed an ultrasound on two lumps which led to a needle biopsy on both.
 Asked: 11/26/2014 I was diagnosed with ILC of my left breast in September.
 Asked: 11/26/2014 I had two biopsies done on two separate lesions on my right breast that were ER+.
 Asked: 11/24/2014 I have 5 pgs of babble but mostly want to know what my odds for survival are and what if any chemo you would recommend...
 Asked: 11/25/2014 I have been told that my breast cancer was high in ki-67 (40).
 Asked: 11/24/2014 hi there.
 Asked: 11/24/2014 Sorry about that. In addition to my first question I am Her2 negative, estrogen & progesterone positive.
 Asked: 11/23/2014 I have 5 pgs of babble but mostly want to know what my odds for survival are and what if any chemo you would recommend...
 Asked: 11/20/2014 Hello, I''m hoping to get help with understanding the stage and prognosis I''m facing based on the following lumpectomy proctology report.
 Asked: 11/20/2014 I am a 53 year old woman considered to be peri-menopausaI.I was diagnosed with DCIS (Sept.
 Asked: 11/20/2014 What does the following diagnosis (both from the same biopsy) mean? 1.Invasive ductal carcinoma with focal necrosis 2.Ductal carcinoma in situ, intermediate nuclear grade, solid and cribriform...
 Asked: 11/19/2014 My ultrasound-guided needle biopsy came back benign, but my surgeon thinks there is a 70% chance it is a carcinoma.
 Asked: 11/18/2014 Following a biopsy of breast please explain the following: the MIB (K-67) report shows - 18% Intermediate / HER-2 (2+) Equivocal .
 Asked: 11/18/2014 "In the lateral aspect of the breast, along the deep margin there is another very hard, highly suspicious nodule which measures 20x10x5mm and this nodule...
 Asked: 11/17/2014 What does it mean on path report when it says tumor 5.
 Asked: 11/17/2014 My report shows tubules 3/3 pleomorphism 2/3 mitotic rate 1/3.
 Asked: 11/17/2014 are positive S100, CD68 and negative pankeratin enough to r/o malignancy in a granulomatous breast tissue involving dermis (nipple)? I thought differential dx for...
 Asked: 11/13/2014 Wow, what a great web site. I just got the pathology report from my DCIS surgery.
 Asked: 11/12/2014 1. If you have had a double mastectomy can you still have radiation 2.
 Asked: 11/11/2014 i had a biopsy and dr tells me it''s benign.
 Asked: 11/11/2014 I have HERS negative, stage 1b, invasive ductal carcinoma with a SBR grade: histolgic grade = 2 nuclear grade = 2 Mitosis score = 1 what does...
 Asked: 11/11/2014 what is the difference between stage 1A and 1B please.
 Asked: 11/6/2014 Hello- perhaps you can help me understand this report: tumor size 6 cm, left breast invasive ductal carcinoma, left axillary lymph node collection of poorly differentiated...
 Asked: 11/5/2014 I should begin this with I don''t feel anything.
 Asked: 10/31/2014 Part of the results also said, I''m not sure what this means.
 Asked: 10/30/2014 Hi there. I had a biopsy at the beginning of treatment and the report came back triple negative 0% staining on ER+ PR+.
 Asked: 10/30/2014 I''m so sorry for all the questions.
 Asked: 10/30/2014 So maybe I don''t need chemo then since it hasn''t broken thru on its own.
 Asked: 10/29/2014 Thanks so much. Forgot to put dr side the invasive cells had not gotten thru the duct walls yet.
 Asked: 10/29/2014 When I was diagnosed with er+ stage 3 breast cancer last year, it was described as very aggressive because it was grade 3.
 Asked: 10/29/2014 I''ve been diagnosed dcis with invasive components.
 Asked: 10/28/2014 My recent mastectomy path report shows invasive carcinoma, pT1c, recurrent near the original site, grade G2, moderately differentiated, clean margins, ER/HR positive HER2 equivocal, pNX...
 Asked: 10/26/2014 Hello! Im diagnost with idc, er, pr+ anf her2 negative.
 Asked: 10/25/2014 I had suspected breast granuloma excision and pathology tested for S100 and CD68 and karoten.
 Asked: 10/25/2014 Diagnosis: Infiltrating ductal carcinoma, poorly differentiated. Microscopic findings: consists of dense fibrous tissue infiltrated by nests and cords of tumor cells showing avoid and polygonal hyperchromatic nuclei For now, this are the only information I know because I don''t have a copy of the pathology results. What stage is this? My mother had mastectomy (not sure what type because we haven''t talked since she was brought to the hospital) a few days ago and we were to be referred to an Oncologist for possible chemo or other treatments 2 weeks from now.
 
 
 
 
 

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