Ask an Expert: Understanding Pathology Results

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Understanding Pathology Results
Questions explaining and understanding pathology results.
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 Asked: 3/3/2015 The biopsy tissue from the right breast shows an invasive ductal carcinoma grade 2.
 Asked: 3/3/2015 Benign breast tissue with periductal stromal fibrosis and focal fibroadenomatoid change.
 Asked: 3/2/2015 How do u know when to stop chemo treatment, so how do u know if your body still has cancer cells in it?
 Asked: 3/2/2015 What does grade 3 -10% carcinoma in situ mean, and invasive breast carcinoma w ductal and lobular features multiple cores, grade 3 DMS/nec, tks.
 Asked: 3/2/2015 Can you tell me what I am looking at? Is this High Grade? Is this Comedo-type? Is the prognosis good for a one-time surgical...
 Asked: 3/1/2015 Hi, I''m 60, have not been on any post-menopausal hormone replacement therapy.
 Asked: 3/1/2015 Hello, Please see my pathology findings below.
 Asked: 3/1/2015 On my final double mastectomy pathology report there is a statement" Microinvasion, focus suspicious, but not diagnostic of microinvasion".
 Asked: 2/27/2015 Thank you for answering questions. I understand that my path report is benign but it seems there can be gray areas.
 Asked: 2/27/2015 I am confused is a focal fibroadenomatoid change the same as fibrodenoma? It does not say hyperplasia just microcalifications.
 Asked: 2/27/2015 1. When a mammotome biopsy is taken of a tumor is some surrounding tissue also sampled? 2.
 Asked: 2/26/2015 Can u please explain this, ER(sp1) 99% intensity 3+ favorable, PgR(1e2) 40% intensity +2 favorable, Ki67(30-9) 10% favorable, tk u so much..
 Asked: 2/25/2015 What does her2/neu non amplified w/her2/CEP ratio 1.2 and mean her2 signal 2.1 mean?
 Asked: 2/25/2015 Post biopsy changes at 9 o''clock position of left breast corresponding to the patient recent diagnosis of dcis .there is a 2.8cm area of linear...
 Asked: 2/25/2015 2.6 cm oval macrolobulated parallel well circumscribed.
 Asked: 2/25/2015 Ms15-950 is the result code.
 Asked: 2/24/2015 What does p53 mean on the pathology report? .
 Asked: 2/23/2015 Final Pathologic Diagnosis (Please explain) "Breast, left, upper inner quadrant, stereotactic core biopsy: Focal atypical ductal hyperplasia associated with mucin production and mucin extravasation
 Asked: 2/22/2015 I have a pathology report after excisional biopsy with finding of invasive ductal carcinmoa grade 1.
 Asked: 2/21/2015 I had a lumpectomy for an intraductal papilloma.
 Asked: 2/20/2015 I had a random fine needle aspiration to participate in a clinical trial because I am at high risk for breast cancer.
 Asked: 2/19/2015 Hello! I want to know about staging.
 Asked: 2/18/2015 I received my pathology report and met with a breast cancer surgeon.
 Asked: 2/16/2015 I was diagnosed last week and things have been a bit scary.
 Asked: 2/16/2015 i had biopsy to confirm breast cancer.
 Asked: 2/15/2015 core biopsy States fibrocystic change consisting of intraductal papilloma sclerotic papilloma with sclerosis and adenosis and focal microcalcification.
 Asked: 2/14/2015 Stage IIA breast cancer with one positive node and one micrometastasis seen on stains. My CEA level prior to lumpectomy, SNB, chemo (taxotere and cytoxin), and...
 Asked: 2/14/2015 Stereotactic biopsy for microcalcifications: SAMPLE 1: included multiple calcs 3.5 x 2.5 x .3 , flat epithelial atypia, columnar cell change, stromal fibrosis,hyalinized fibroadenomatoid...
 Asked: 2/12/2015 Thank you for your answer and sorry that i didnt mention that my tumor was 2.5 santimeter and my stage is 2a.
 Asked: 2/12/2015 Hello, I get the pathology report after the surgury (i have finished chemotherapy) and i want to underatand what this is mean to further treatment...
 Asked: 2/10/2015 Hi. I have some questions regarding staging, survival rates, Micrometastatic (0.2mm) in lymph 1 lymph node, and use of Tamoxifen. I am around 45 old, diagnosis of 96% ER+, 89% PR+, Infiltrating Ductal Carcinoma.
 Asked: 2/10/2015 I am sorry to ask, but I am really confused.
 Asked: 2/9/2015 What grade is a Nottingham score of 5?
 Asked: 2/9/2015 Is a score of 5 on the Nottingham scale always a Grade I? Does the pathologist have discretion to assign a Grade II, even when...
 Asked: 2/9/2015 Thank you very much on your answers and help! I know that from the start i had 2 nodes affected, after surgury still microscopic cells found...
 Asked: 2/9/2015 Hello, My mother is 65y/o diabetic for the last 15 years using insulin.She is recently diagnosed with invasive ductal carcinoma grade-111.She has estrogen and progesterone receptors...
 Asked: 2/9/2015 What does it mean to have metaplastic features? Is that the same as metaplastic cancer? Diagnosis from biopsy: invasive ductal carcinoma with metaplastic features.
 Asked: 2/8/2015 Hello! Im a young women who treated with chemotherapy for breast cancer stage 2a. After the chemo im complete with surgury and the pathologic results were...
 Asked: 2/8/2015 Invasive ductal carcinoma, 49 years old, 2.3 cm, mastectomy left breast ,margins clear, no radiation, er+ 90% pr+ 80% ki67 7 % , her2...
 Asked: 2/7/2015 My breast biopsy results: Focal atypical ductal hyperplasia, measuring less than 1mm Papilloma with fibrosis and glandular entrapment Adenosis with micro calcification *pathologist comment: seven h&e levels have...
 Asked: 2/7/2015 Breast Right Fibroadenoma with myxoid change --the lesion focally involves an undesignated margin Surrounding breast tissue with mammary fibrosis, usual ductal hyperplasia, microcysts, and apocrine metaplasia. -negative for epithelial...
 Asked: 2/7/2015 I had and with one positive node and lvi but no extra nodal extension seen.
 Asked: 2/6/2015 I just received my core needle biopsy report: "pathology from the left breast ultrasound-guided biopsy shows sclerosing adenosis and focal stromal hyalinization
 Asked: 2/5/2015 My wife was diagnosed last May with triple negative stage 2 in right breast.
 Asked: 2/3/2015 Completed bilateral mastectomy, 4 rounds of TC chemo, and have been on Tamoxifen for 1.8 cm T1N0M0 tumor in late 2013 at the age of 43.
 Asked: 2/2/2015 I received my pathology report.
 Asked: 2/2/2015 Just diagnosed with DCIS with small 2mm section that had infiltrated outside of duct.
 Asked: 2/2/2015 My Her-2 status for the biopsied tissue came back as 2+(equivocal) so a FISH test was ordered.
 Asked: 1/31/2015 Is a Magee score of 20 equivalent to an Oncotype DX score of 20? Does a Magee score of 20 mean that there is...
 Asked: 1/28/2015 Please see summary of histology below. Should Lymph nodes also be investigated? Is radiotherapy advised? Do I have cancer? Thank you very much! Mandi Bouwer SUMMARY LUMPECTOMY: TUMOUR LOCATION: Left breast TUMOUR QUADRANT: supero-lateral TUMOUR SIZE: Macroscopic: 6 mm Microscopic (on immunohistochemical marker): 4.5 x 3.5 mm TUMOUR TYPE: Invasive lobular carcinoma - Tubulolobular type GRADE: Not applicable EXTENT OF INVASION: Primary tumour (pT) pT1a: Tumour more than 0,1 cm but not more than 0,5 cm in greatest dimension REGIONAL LYMPH NODES (pN): pNX: Cannot be assessed (previously removed or not removed for pathologic study) RESECTION MARGINS OF INVASIVE TUMOUR: Marginal CLOSEST RESECTION MARGIN: 1 mm anterior DISTANCE FROM DEEP FASCIA: Cannot be assessed NIPPLE: Cannot be assessed SKIN INFILTRATION: Cannot be assessed LYMPHOVASCULAR INFILTRATION: Absent PERINEURAL INFILTRATION: Absent MULTIFOCAL (MORE THAN ONE QUADRANT) Cannot be assessed RECEPTORS: Oestrogen receptors - to follow Progesterone receptors - to follow c-erbB-2 - to follow CARCINOMA IN-SITU: Carcinoma in situ present TYPE: Atypical lobular hyperplasia and lobular carcinoma in-situ LOBULAR CARCINOMA IN SITU: % of whole tumour represented by carcinoma in situ: >20% RESECTION MARGINS OF CARCINOMA IN SITU: Marginal 1.5 mm REST OF BREAST: Fibrocystic change AXILLARY DISSECTION: Not done Immunohistochemical markers: Oestrogen receptor - 2+ positive in 80% of tumour cells. Progesterone receptor - 3+ positive in 50% of tumour cells. HER-2 - negative COMMENT: A small invasive tubulolobular carcinoma is present with a larger component of atypical lobular hyperplasia and lobular carcinoma in-situ (pT1a).
 Asked: 1/26/2015 I''m 48 years old. had a lumpectomy and SNB, 1/3 nodes was positive and margins were close.
 Asked: 1/24/2015 5 years ago I had atypical papilloma and atypical columnar cells removed near nipple on same breast.
 Asked: 1/23/2015 sterotactic biopsy of microcalcifications path report shows flat epithelial atypia, columnar cell change, microcysts, stromal fibrosis, hyalinized fibroadenomatoid change
 Asked: 1/22/2015 57 years old, ductal carcinoma in situ, invasive ductal, 0.8 cm lumpectomy, clear margins, Her2 negative, two lymph nodes removed, SLNB, results both were negative
 Asked: 1/22/2015 Age 61 found lump 2-3 0''clock left breast needle core bipsy 12mm on ultrasoujd, only 8m on core biopsy, hist grade 2 IDC, no definite...
 Asked: 1/22/2015 Thank you for answering my question about the one close margin reported in my pathology report after lumpectomy.
 Asked: 1/23/2015 What does a Magee score of 20 mean?
 Asked: 1/21/2015 What does invasive matrix producing ductal carcinoma moderately differentiated (Nottingham grade 2) mean???
 Asked: 1/23/2015 Hi! My radiology report states the following: The neoplastic cells are positive for CD31 and CD34.
 Asked: 1/21/2015 Margins: I got my pathology today after my lumpectomy for what had been diagnosed, after stereotactic biopsy, as Grade 3 DCIS.
 Asked: 1/21/2015 I had an ultrasound done after finding 2 lumps, one in and one above my right breast.
 Asked: 1/20/2015 Hi, I was diagnosed and had surgery for papilloma in my right breast in November.
 Asked: 1/18/2015 I underwent lumpectomy, 10/22 lymph node + HER 2+ in February 2014, followed by 6 rounds of chemo concurrent (and still on) Herceptin, 33 radiation...
 Asked: 1/18/2015 I''m over 2 years out from treatment for Stage III TNBC.
 Asked: 1/17/2015 Hi.
 Asked: 1/15/2015 Hi Iím having a hard time understanding these results from my vacuum assisted biopsy.
 Asked: 1/15/2015 Hello i had a lumpectomy on left breast and a palpable mass removed on right: results or confusing.
 Asked: 1/15/2015 Hi - I have a strong family history of breast cancer.
 Asked: 1/14/2015 I had an ultra sound guided biopsy and my doctor told me that the results were that I have an atypical papilloma.
 Asked: 1/14/2015 All things being equal, is it better to,have a grade 2 or grade 3 tumor? Is it true grade 3 will respond better to chemo...
 Asked: 1/14/2015 Hello, I am a 54 y/o white female.
 Asked: 1/14/2015 I had my first mammogram in November.
 Asked: 1/9/2015 I will consider JH for second opinion considering what is said with general surgeon on appointment next week.
 Asked: 1/9/2015 I had breast reduction surgery Oct. 31pathology report states I have atypical ductal hyperplasia.
 Asked: 1/9/2015 Hi, my mother in law (60 y/o white) is dx''ed with: Poorly differentiated infiltrating ductal carcinoma with tumor necrosis. I am a dietitian so aware that poorly...
 Asked: 1/8/2015 Hi Thanks for your previous response since you were not able to connect my first post to the second one I combine them as follow. My...
 Asked: 1/7/2015 Thanks so much for your respond. If you remember my mom is 72 and I posted her pathology lab result, I just got her second result as follow: ER: Positive 95% PR:Positive 95% HER-2 Eqivocal (2+) Ki67: 10% My mom said she a scan done before her surgery and her other organs were fine.
 Asked: 1/5/2015 Hi, my mom (72 yrs) is out of state and I am worried and need help to know what is the best treatment option for her.
 Asked: 1/4/2015 Pathology came back with a report of focal rare ducts partially involved with early atypical ductal hyperplasia (ADH), intraductal papillomatosis, florid ductal hyperplasia, multiple cycts,...
 Asked: 1/2/2015 How much weight or predictive reliability can be given to an oncotypedx score for dcis? Thanks for your wonderful service!
 Asked: 1/2/2015 path: (1) a single focus of microinvasion of DCIS, intermediate nuclear grade, solid and cribriform types, with associated microcalcifications.
 Asked: 1/1/2015 How do yo determine tumor size when biopsy site is 1.7 x 1.7 x 1.5 cm with 0.3cm from the closed inked lateral margin when...
 Asked: 1/1/2015 What stage is this? I got my stereotactic biopsy last week.
 Asked: 12/28/2014 I recently had a breast biopsy and the pathology was DCIS nuclear grade 3 with solid and cribriform and comedonecrosis.
 Asked: 12/27/2014 "Invasive carcinoma, favor pleomorphic lobular, histologic grade 3 and nuclear grade 3." What does it mean??pls help.I''m worried abt my mom!
 Asked: 12/26/2014 What does positive 1+ staining in 2-3% of nuclei and negative 1+ staining in less than 1% of nuclei mean?
 Asked: 12/24/2014 I have a biopsy report which says Ductal carcinoma in-situ grade II with few foci suspicious of invasion My doctor wants to do a lumpectomy and a...
 Asked: 12/23/2014 Thank you for answering my previous question regarding the mucinous cancer.
 Asked: 12/22/2014 My HER2 status came back equivocal on IHC and FISH.
 Asked: 12/22/2014 First off'' I want to thank you for what you do.
 Asked: 12/22/2014 I was diagnosed with right breast Stage 1 Grade 2 T1b (9mm) N0 (0/) M0 invasive micropappilary cancer with lymphovascular invasion and Grade 2 DCIS.
 Asked: 12/21/2014 I was dx. with IDC, Stage II, grade 2 via core biopsy.
 Asked: 12/21/2014 I have read where if you have micropapillary patterns present in your invasive ductal carcinoma that recurrence rates are high even if mastectomy was done
 Asked: 12/19/2014 I was diagnosed with intraductal papillomata with calcifications and intraductal papilloma with rare calcifications.
 Asked: 12/18/2014 I was diagnosed with a complex sclerosing lesion with micro calcifications measuring 22mmx16mmx13mm after MRI guided core needle biopsy on 12/10.
 Asked: 12/16/2014 Follow up to your reply on 12/15.
 Asked: 12/15/2014 I have been diagnosed with 1cm cancer ER+, PR weakly positive, HER 2 negative and Ki- 67 58%. Original recommended treatment was lumpectomy, radiation, anti hormonal...
 Asked: 12/15/2014 I had an ultrasound-guided core needle biopsy performed a week ago.
 Asked: 12/15/2014 Hello I got my biopsy back The doctor said I had microcalcifications.
 Asked: 12/12/2014 Microscopic examination of a FNA indicated: 1) A few papillary structures.

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