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|Concerns about Breast Cancer Family History
Questions on genetics, family history & breast cancer.
|Asked||Publicly Submitted Question|
|9/2/2010||Hi there. My maternal grandmother was diagnosed with breast cancer in her mid-thirties and died in her mid-forties. My mother was first diagnosed with breast cancer in her early forties and battled the disease for many years until she died this year at age 66. My mother, and my 2 sisters all tested positive for BRCA 2. I recently was tested for BRCA 2 and was negative. The lab then tested for BRCA 1 and that was also negative. I am 35 years old. I was called back from my yearly mammogram due to an area of concern. This week I had an ultrasound guided core biopsy which came back as a benign fibrocystic change. My radiologist suggested I have a scan every 6 months for the rest of my life -- mammogram in summer, then breast MRI in winter since although I'm gene negative, I still have a significant family history. I do not know if I can mentally handle the emotions of doing this every 6 months and waiting each time. Are bilateral mastectomies still an option for me based on family history, or is that too drastic an option based on my genetic test? My oldest sister has already had the surgery and reconstruction, as well as her ovaries removed, and is doing great. My other sister is currently considering her advice. Thanks for your advice. I have also called your BOSS program and they are sending me information. Thanks!|
|Replied||JHU's Breast Center Reply|
|9/2/2010||I'm glad that you have called our BOSS program as I think that will be helpful for you to sit and discuss what your "real risk" is given you are (blessedly) gene negative. your risk should then be similar to that of the average population. your family knows why these other dear women got breast cancer--- BRCA 2 positivity. Though you could do bilateral mast with reconstruction given your gene negative status it would be unusual to do since your risk isn't like someone BRCA positive. let's see what the BOSS doctors tell you but I suspect you will be okay doing annual mammograms.|
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