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|Forum||Questions||Ask a Question|
|Understanding Pathology Results
Questions explaining and understanding pathology results.
|Asked||Publicly Submitted Question|
|9/1/2011||My Oncotype test came in at 22. I am taking your advise and sending my pathology slides for a 2nd opinion. I'm hoping to get a clear answer on my lymph nodes. Final pathology says SN is negative, but two other lymph nodes are "possible lymph nodes" and are positive for micromets. Oncologist still recommends chemo, but not TAC and instead just T & C. This is overwhelming since Oncotype wasn't low and wasn't high. If I end up with only 1 node (or maybe no nodes positive) would chemo still be recommended?|
I am 46 years old, IDC, 1.2cm, Grade 1, Stage 1B, MAYBE 2/6 nodes, ER+ PR+, Her- and BRCA-. Thanks so much for answering!
|Replied||JHU's Breast Center Reply|
|9/1/2011||When Oncotype scores return as either low, or high, indication for chemotherapy is more clear. When scores return in the intermediate range, then careful discussion with breast medical oncologist, and personal decision making comes into play. Oncotype will predict the likely benefit of chemo but not which regimen is better than the other. For that we have to go on clinical data and we don't know whether TAC is better than TC though there is an ongoing trial to compare the two. That said, that trial is comparing 6 cycles of TC vs. the normal 6 cycles of TAC. Currently the approved regimen for TC is 4 cycles.|
TC x4 is a very good regimen with solid data behind it. Given the features of your tumor and your oncotype score (even with micromets which are likely not to be a clinically important as we once thought based on newer data), TCx4 would be a very reasonable approach. Hope this helps, and best wishes!
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