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Understanding Pathology Results
Questions explaining and understanding pathology results.
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AskedPublicly Submitted Question
10/8/2013One week ago I had a double mastectomy. I had a tumor in my right breast, nothing in my left breast. I visited my oncologist yesterday and he went over the pathology report and said I needed chemotherapy. Why? Also, there was no cancer in either of the 2 lymph nodes tested, and my BRCA1 & BRCA2 tests were negative.
The pathology reads:
Tumor size: 1.5cm
Tumor focality: Single focus of invasive carcinoma
Skin: doesn't invade into dermis or epidermis
Nipple and DCIS: DCIS doesn't involve the nipple epidermis
DCIS: DCIS is present and positive for EIC
DCIS dimensions: 2cm
Architectural patterns of DCIS: Solid
Nuclear grade of DCIS: Grade 2
Necrosis of DCIS: not identified
Lobular Carcinoma: Absent
Type of invasive carcinoma: Invasive ductal carcinoma (NOS)
Margins of DCIS: margins uninvolved by DCIS
Location closest margin: superior radial margin
Distance from closest margin: 2mm
Margins - Invasive: margins uninvolved by carcinoma
Location closest margin: superior radial margin
Distance from closest margin: 1mm
pTNM staging: pT1c, pN0, pM0.
Prognostic markers performed prior to case: Yes, S13-40089
Estrogen Receptor: 86%
Progesterone Receptor: 67%
Her-2/neu score: 0
RepliedJHU's Breast Center Reply
10/9/2013From what you share you have an early stage breast cancer, with very favorable factors (stage 1, ER positive, node negative)

Ask your oncologist about sending out your breast cancer tumor slides for the Oncotype DX test, a 21 gene assay that evaluates your individual breast cancer, and reports back a risk of recuurence score, as well as a benefit of chemotherapy.

And seek a second opinion with a breast medical oncologist familiar with the Oncotype DX (perhaps at an academic medical breast center even if you have to travel a bit). If we can help, please call 443-287-BRST (2778) to schedule appointment.

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