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AskedPublicly Submitted Question
1/30/2015I started tamoxifen in Nov. 2013. In Nov. 2014 I read that wellbutrin and prozac can interfere with the efficacy of tamoxifen. I had been taking 200mg of wellbutrin and 20mg of prozac daily during my first year on tamoxifen. After reading about the inhibiting effects of both of these meds on tamoxifen I weaned myself off both of them. My oncologist did not seemed concerned about the inhibiting effects of these meds on tamoxifen. About two months after stopping my antidepressants, the side effects of tamoxifen started kicking in. I have gained weight, my joints are aching, I am moody and have night sweats. I do not mind these side effects as it means (I assume) that the tamoxifen is doing its job. Now I am worried that my first year on tamoxifen was a complete waste and cancer is lurking. I am scared.
RepliedJHU's Breast Center Reply
1/31/2015You were wise to pursue this and you now have tamoxifen working the way it should. don't look backwards though. we aren't going that way, nor should you. it doesn't mean you go no benefit at all either during that first year. taking it as prescribed is key. frankly more than 60% of women don't take it as prescribed, including during the first year, due to side effects so you will get far more benefit than those who have traveled that nonadherence road.

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