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Concerns about Breast Cancer Family History
Questions on genetics, family history & breast cancer.
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AskedPublicly Submitted Question
3/14/2016My wife, her brother and her sister all have breast cancer, the first two are metastatic. No other siblings. All tested negative for BRCA. Approx. ages at diagnosis were 50, 58 and 57. Their mother died of lung cancer age 79. Their father's sister also had breast cancer. Here in the UK mammogram screening begins at age 50, which is when my wife was first diagnosed in 2009. She has since had 2 local recurrences and now mets in bone and liver. I am wondering about the implications for our children - one daughter and two sons.
RepliedJHU's Breast Center Reply
3/17/2016though testing negative, this is a classic description of a family with a breast cancer gene of some type. screening really should be happening starting at 40 or even at 35. worth paying out of pocket for mammography if not covered otherwise. when men carry a breast cancer gene their risk is only 6%. for women though it usually is 60-80%. so when daughters get older, consider prophylactic mastectomies with reconstruction is a reasonable thing to think about.

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