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Concerns about Breast Cancer Family History
Questions on genetics, family history & breast cancer.
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AskedPublicly Submitted Question
6/19/2017Hello, I'm 44 stage 3c ductal carcinoma w/lobular features. 2.7-5cm tumor 12/12 lymph positive. ER 100%/PR + HER negative. No markers in genetic testing results but since diagnosis found my birth family and on my birth fathers side my great grandmother, grandmother and great aunt all died of breast cancer. Should I be considering more aggressive treatment than lumpectomy, chemo, radiation, AI?
RepliedJHU's Breast Center Reply
6/19/2017usually chemo done first to shrink tumor size and nodal involvement. then surgery, then radiation. then hormonal therapy. that said, your family history is significant. your dad may have a gene mutation of some sort that was passed along to you. given your young age, you may want to take a look at more aggressive surgical management for prevention of local recurrence or a new primary in the other breast. worth discussing in any case. Stage 3c is tough. hormonal therapy will need to become your new best friend.

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