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Concerns about Breast Cancer Family History
Questions on genetics, family history & breast cancer.
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AskedPublicly Submitted Question
7/15/2017Hi! Diagnosed with bc in both breasts (sincronic) at 42. IDC, Stage IIA (1 node affected)T1c N1 M0 in one breast and DCIS, Stage 0 in the other breast. Intermediate grade. Both ER+ PR+ Herneu negative. Mu mum had bc at 56 and colon cancer at 68. One of my mum's sisters had colon cancer at 45. One of my brothers had thyroid cancer at 33 too. With all this family and personal history I was tested for BRCA1 and BRCA2. Results were negative but they didn't do big rearrangemets and deltions of BRCA1 and BRCA2(MLPA technique) If I have MLPA of BRCA1 and BRCA2 done... 1)What is the probability to have a positive gene mutation? 2) Is it possible to be negative before and be positive now? 3) If positive what it'd imply to me and my family? What can we expect and do after knowing positive results? 4) If negative, does it mean y family and I have had cancer by chance and not related to gentics? Are there other causes such as diet, habits,....? Thanks.
RepliedJHU's Breast Center Reply
7/16/2017might be the Lynch syndrome gene. you have a high enough risk factors for getting tested for this gene mutation.

can't be negative now then positive later.

50% of siblings and offspring will have the same gene mutation if one is found.

question 4 -- yes, however there are genes that we don't have a way of testing for yet. other causes for breast cancer are smoking, alcohol, sedentary lifestyle, obesity, HRT. but 70% of women have no known risk factors who are diagnosed.

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