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Concerns about Breast Cancer Family History
Questions on genetics, family history & breast cancer.
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AskedPublicly Submitted Question
9/10/2017Hi, I am 47. Had bilateral lumpectomies 10 wks ago. Left DCIS pTis pNXnuclear grade 2, focal comedo necrosis present, 1.1 cm, negative for invasive tumor, clear margins. Right ILC pT1b pN0, Nottingham grade 2, unifoval tumor, 1 cm, lymphovascular invasion not detected, clear margins. Both background breast tissue showing sclerosing adenosis with multifoval flat epithelial atypia (ductal intraepithelial neoplasia 1A) showing associated microcalcifications. Two lymph nodes on the right biopsied negative. Family history of cancer. Dad and brother dies of pancreatic cancer. Brother tested positive for brca2. Two sisters breast cancer at 29 and 40 respectively, not tested for genetic mutation. I have tested negative for brca and all other known mutations. Oncotype dx score for right tumor 14. ER+ 8/8, PR+ 8/8 Her2- 1+/3. My RO thinks BMX may be best for me given bilateral bc at relatively young age and strong family history even though I tested negative for mutation, although radio remains an option. I can skip radiation if BMX and avoid risks arising from radio. No chemo prescribed. It has been a struggle to decide. Would appreciate your input.
RepliedJHU's Breast Center Reply
9/11/2017Good news that are don't carry the gene your other siblings do. that said, most women still opt for bilateral mastectomies with reconstruction. it lets you skip radiation and it lets you also skip future mammograms.

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