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Concerns about Breast Cancer Family History
Questions on genetics, family history & breast cancer.
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AskedPublicly Submitted Question
9/25/2017I have a question regarding genetic testing. I have several maternal aunts and one paternal aunt that has/had breast cancer. There is also lung cancer on both maternal and paternal side, Ovarian on maternal, Colon cancer on maternal, thyroid cancer on paternal (my dad), and Leukemia on maternal side too. My sister (age 49) was just diagnosed with IDC stage 2, ER/PR+, HER2+. She had genetic testing for BRAC 1 and 2. Her testing came back negative. Does that mean I am automatically Negative? I thought I read somewhere that we get a copy of each from mother and father? Is this Correct? So, if she's negative, is it possible that I could still be positive if I inherited it from my father's side? I also had an abnormal mammogram and ultrasound. Had recent biopsy. Breast surgeon didn't think it was necessary to do genetic testing on me but she would have if my sisters came back positive. I'm just trying to understand this and want to make sure I'm doing everything possible regarding any genetic disposition. Thank you for reading and replying at your convenience.
RepliedJHU's Breast Center Reply
9/25/2017Ideally, it is best to test those who have had breast or ovarian cancer. if they test negative then usually it is felt that there isn't a gene. your mom's side of the family is more riddled with ovarian and breast cancer than your dad's making your mom's side more likely to have a gene mutation. make sure your sister was tested for ALL known gene mutations and not just for BRCA 1 and 2.

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