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AskedPublicly Submitted Question
11/5/2017Lillie can you tell me what this means: (thank you)
Right nipple sparing mastectomy:
Invasive Carcinoma: Ductal with prominent stromal lymphocytic infiltrate
Size: Microscopic measurement 0.6 cm
Histologic Grade: III/III: minimal or no tubule formation (< 10% of tumor) [score 3]
Nuclear Grade: III/III (marked variation in size and shape) [score 3]
Mitotic Count: >= 17 mitoses per 10 high power fields [score 3]
Overall Tumor Grade: Combined score 9: grade III/III (poorly differentiated)
Ductal Carcinoma in Situ (DCIS):Identified
Total number of slides with DCIS: 3 Total number of slides examined: 14
Extends into lobules
The largest of focus of DCIS measures 0.8 cm on one slide
DCIS Architectural Pattern: Solid Cribriform Micropapillary
DCIS Nuclear Grade: Intermediate to high
Necrosis in DCIS: Minimal
Extensive intraductal component (>=25% of total tumor mass):
Identified: Around the invasive carcinoma
Lobular Neoplasia: Lobular carcinoma in situ (LCIS), classical type
Atypical lobular hyperplasia (ALH)
Location of Invasive Carcinoma: Upper outer quadrant (UOQ)
Location of DCIS: Upper outer quadrant (UOQ)
Calcification: In benign epithelium
Lymphovascular Invasion: Not identified
Surgical Margins: DCIS is <= 1 mm from the axillary tail margin
No involvement of the surgical margin(s) by invasive carcinoma

RepliedJHU's Breast Center Reply
11/5/2017you had a lot going on inside of the breast tissue. several types of breast cancer-- invasive and insitu as well as markers for risk as well. grade 3-- rapidly growing. one area of concern is the axillar tail margin. this is the breast tissue underneath and below your underarm area. there was DCIS within 1mm of that margin. that margin still needs to be cleared. so could mean a little more surgery.

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