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Survivorship Care Issues
Questions surrounding survivorship and life after cancer.
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AskedPublicly Submitted Question
11/23/2017Hi Lillie,
Have any Johns Hopkins oncologists lowered medication doses for aromatase inhibitors or biphosphinates for the very small adult patients?
I had severe side effects with bone/joint pain that crippled me. MDís are forcing me to choose an overdose or none at all. Due to my positive cardiac family history I am not able to take tamoxifin or exemestane. I took myself off the drug anastrozole (also tried letrozole) and symptoms significantly reduced. I cancelled my option for a hip replacement based on this. Why arenít clinical trials adjusting dose to size. Pediatric doses have been trialed. We can start there for the small adult.
Oncotype DX is 20. Would the mammaprint guide this decision for us? UCSF is testing the mammaprint. Is Johns Hopkins doing the same and comparing the Oncotype to the mammaprint? If so I would like to participate in a clinical trial. Can that be done at a distance?
RepliedJHU's Breast Center Reply
11/25/2017not that I am aware of. the dosage has never been based on body volume.

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