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LCIS - Lobular Carcinoma In Situ
Questions about lobular carcinoma in situ.
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AskedPublicly Submitted Question
1/27/2018Hi - I'm 55, not close to being menopausal, with dense breast tissue, a slew of cysts in both sides and am trying to decide on next steps. On the right side biopsy findings were lobular carcinoma in siitu, atypical lobular hyperplasia, extensive, and radial scar. Also noted was fibroadenomatiod change and fibrocystic changes with usual duct hyperplasia. On the left side biopsy they found lobular carcinoma in situ, flat epithelial atypia associated with coarse microcalcifations. Also noted fibocystic changes with usual ductal hyperplasia and apocrine metaplasia. Basically no family history of breast or other cancers. Recommendation is for excision of both LCIS sites which I am fine with but long term findings of people with LCIS and all of these other conditions looks grim. I've tried to review medical studies published over the past ten years and findings regarding LCIS and long term cancer rates keep changing. What are the latest recommendations? Have found many sites saying 3 options - close monitoring every 6 months, tamoxifen, and BMX but nothing showing specific follow up on people choosing monitoring, and nothing on side-effects of people on tamoxifen with LCIS. (have seen reduction of breast cancer rates from tamoxifen but nothing on side effects) - thanks for your input
RepliedJHU's Breast Center Reply
1/28/2018LCIS is not breast cancer. We would surgically remove atypical lobular hyperplasia as well as radial scar lesions. Tamoxifen (or any anti-hormonal drug) side effects are very similar to menopausal symptoms: hot flashes, vaginal dryness, etc. The monitoring would include breast imaging and the frequency would be determined by a breast radiologist based on your specific circumstances.

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